Document Detail


Pulmonary function after high-dose chemotherapy with autologous bone marrow transplantation and radiotherapy in patients with advanced loco-regional breast cancer.
MedLine Citation:
PMID:  9066577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our aim was to study the extent of pulmonary toxicity after high-dose chemotherapy and radiotherapy in breast cancer patients. In a retrospective study the pulmonary symptoms and chest X-rays were analyzed before, during and after treatment in 17 patients, treated with loco-regional radiotherapy to the breast/chest wall and the regional lymph nodes after the completion of high-dose chemotherapy and autologous bone marrow transplantation for locally advanced breast cancer. Lung function was evaluated between 15 and 46 months after completion of the irradiation. Nine patients (53%) had pulmonary symptoms during and/or within two months from irradiation. Radiographic changes were seen in twelve patients (71%) and a decreased diffusion capacity occurred in nine patients (53%). The spirometric values (VC and FEV1) were abnormal in two patients (12%). There is a high incidence of radiation pneumonitis, although no consistent correlation between the various parameters (pulmonary symptoms, chest X-rays and lung function tests) could be found.
Authors:
W V Dolsma; E G De Vries; T W Van der Mark; D T Sleijfer; P H Willemse; W T Van Der Graaf; P O Mulder; B G Szabó; N H Mulder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  17     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-03-28     Completed Date:  1997-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  537-40     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, University Hospital Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Bone Marrow Transplantation
Breast Neoplasms / drug therapy,  physiopathology*,  radiotherapy
Female
Forced Expiratory Volume / drug effects,  radiation effects
Humans
Lung / drug effects*,  physiopathology,  radiation effects*
Middle Aged
Retrospective Studies
Vital Capacity / drug effects,  radiation effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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