| Pulmonary function abnormalities in thalassemia patients on a hypertransfusion program. | |
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MedLine Citation:
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PMID: 7367114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary function tests were performed in 12 thalassemia patients on a hypertransfusion program (age 18.4 +/- 2.6 SEM years) to determine the presence of any abnormalities of lung function. These included spirometry, expiratory flow rates, body plethysmography, single-breath nitrogen washout, single breath carbon monoxide diffusing capacity, and arterial blood gases. Only one patient had normal pulmonary function. Arterial hypoxemia was present in ten of 12 patients at rest. The total lung capacity (TLC) was normal. The residual volume was abnormally increased in five of 12 patients. The slope of phase III of single breath nitrogen washout curve was abnormal in five of 12 patients, but the closing volume was normal. The maximal expiratory flow rate at 60% total lung capacity was decreased in four of 12 patients, suggesting the presence of small airway disease. The single breath carbon monoxide diffusing capacity was normal in all patients. These pulmonary function abnormalities did not correlate with age or the cumulative amount of iron via blood transfused. The small airway obstruction, hyperinflation; and hypoxemia observed in thalassemia patients on a hypertransfusion program may result from the basic disease, iron deposition in the lungs, or other factors. |
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Authors:
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T G Keens; M H O'Neal; J A Ortega; C B Hyman; A C Platzker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 65 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-06-25 Completed Date: 1980-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1013-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Airway Resistance Blood Gas Analysis Blood Transfusion* Child Closing Volume Female Forced Expiratory Flow Rates Forced Expiratory Volume Humans Lung / physiopathology* Male Maximal Expiratory Flow-Volume Curves Peak Expiratory Flow Rate Plethysmography, Whole Body Pulmonary Diffusing Capacity Thalassemia / physiopathology*, therapy Total Lung Capacity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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