Document Detail

Pulmonary fibrosis: a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
MedLine Citation:
PMID:  7272934     Owner:  NLM     Status:  MEDLINE    
A pediatric patient is reported who experienced fatal progressive pulmonary fibrosis as a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. The patient received a cumulative dosage of 1.29 g (1.72 g/m2) over a two-year period as adjuvant therapy for a medulloblastoma. Two and one-half years after cessation of therapy, cough, tachypnea and fatigue were noted. Progressive pulmonary insufficiency developed. Pulmonary pathologic findings included interstitial fibrosis and alveolar dysplasia. Other cases of BCNU pulmonary toxicity are cited from the medical literature.
B R Ryan; T R Walters
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  48     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  909-11     Citation Subset:  AIM; IM    
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MeSH Terms
Brain Neoplasms / drug therapy
Carmustine / adverse effects*
Child, Preschool
Medulloblastoma / drug therapy
Pulmonary Fibrosis / chemically induced*
Reg. No./Substance:

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