Document Detail


Pulmonary fibre burden in sheep living in the Biancavilla area (Sicily): preliminary results.
MedLine Citation:
PMID:  15144777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a national survey on mortality from malignant pleural neoplasms in Italy, aimed at detecting geographic clusters of cases of the disease, the town of Biancavilla, located in a volcanic area of Eastern Sicily, showed high risk of pleural mesothelioma in the absence of occupational asbestos exposure. An environmental survey suggested the stone quarries located in 'Monte Calvario', south-east of the town of Biancavilla, as a possible source of asbestiform fibre exposure. A subsequent crystal-chemistry investigation of the 'Monte Calvario' amphiboles identified the mineral asbestiform fibres as 'fluoro-edenite', a new end-member of the edenite ==> fluoro-edenite series. A collaborative epidemiological and environmental study was initiated to investigate the characteristics of the outbreak of malignant mesothelioma and test the hypothesis of a causal association with exposure to naturally occurring fibres. To investigate if a sheep population could be used to monitor the environmental diffusion of the fibres, we examined lung specimens from 27 culled sheep, at least 3 years old and living near Monte Calvario to check for the presence of fluoro-edenite fibres, using scanning electron microscopy (SEM) analysis and X-ray microanalysis. Fourteen mineral species have been isolated in the mineral particulate matter taken from pulmonary parenchyma, and fluoro-edenite was detected in eight sheep. These preliminary data suggest a possible bio-indicative role of sheep as sentinel animals in the evaluation of environmental fibre diffusion, which merits further investigation.
Authors:
Paola DeNardo; Biagio Bruni; Luigi Paoletti; Roberto Pasetto; Bruno Sirianni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Science of the total environment     Volume:  325     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-17     Completed Date:  2004-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
Copyright Information:
Copryright 2003 Elsevier B.V.
Affiliation:
Department of Environmental Health, Istituto Superiore di Sanità, Viale Regina Elena no. 299, 00161 Rome, Italy. paola.denardo@iss.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Asbestos / analysis*,  pharmacokinetics*
Biological Markers / analysis
Data Collection
Diffusion
Electron Probe Microanalysis
Female
Humans
Lung / chemistry*,  pathology
Microscopy, Electron, Scanning
Mineral Fibers / analysis*
Public Health
Risk Assessment
Sheep
Sicily
Tissue Distribution
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Mineral Fibers; 1332-21-4/Asbestos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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