Document Detail

Pulmonary feedback and gestational age-dependent regulation of fetal breathing movements.
MedLine Citation:
PMID:  18841174     Owner:  NLM     Status:  MEDLINE    
Prenatal lung development requires fetal breathing movements (FBM). To investigate the dependence of FBM on feedback originating from the lung, we hypothesized that pneumonectomy stimulates FBM. Time-dated fetal sheep underwent bilateral pneumonectomy, unilateral pneumonectomy, or sham surgery at 125-130 days gestation. The incidence of FBM decreased in sham-operated fetuses at 142 days versus 130 days (p = 0.013), but was unchanged across all gestational ages in bilaterally pneumonectomized fetuses (p > or = 0.52). In unilaterally pneumonectomized fetuses, the incidence of FBM remained unchanged until 139 days and was higher than that of the bilaterally pneumonectomized fetuses at 130-136 days gestation (p < or = 0.03). The amplitude of integrated diaphragmatic electromyographic activity (integralEMG(di)) and total respiratory output (frequency of breathing x integralEMG(di)) were lower in pneumonectomized fetuses versus sham-operated fetuses at later gestational ages (p < 0.05). These decreases in integralEMG(di) and total respiratory output were most pronounced at 142 days in bilaterally pneumonectomized fetuses versus sham-operated fetuses (p = 0.006 and 0.016, respectively). Low-voltage electrocortical activity (ECoG) increased, and high-voltage ECoG decreased, in unilaterally pneumonectomized fetuses compared with sham-operated fetuses (p = 0.04). In conclusion, we provide new evidence that feedback from the fetal lung modulates the incidence and various components of phrenic nerve output, suggesting a positive feedback mechanism between FBM and lung development.
Shabih U Hasan; Baikunth Bharadwaj; John E Remmers; Avni Patel; Anita Rigaux; Jennifer Schneider
Related Documents :
3509194 - Measurement of the fetal urine production rate using real-time ultrasound in fetuses wi...
20503244 - Depth of brain fissures in normal fetuses by prenatal ultrasound between 19 and 30 week...
11689994 - Implications of antenatal ultrasound screening in the incidence of major genitourinary ...
25236824 - Current management and prevention of malaria in pregnancy:a review.
10685294 - Influence of postdatism and meconium on fetal erythropoietin.
20447624 - Successful multiple pregnancy achieved after transfer of frozen embryos obtained via in...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  86     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  691-9     Citation Subset:  IM    
Departments of Pediatrics, Physiology and Surgery, Institute of Maternal and Child Health, Faculty of Medicine, Health Sciences Centre, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N4N1, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Gas Analysis
Blood Pressure / physiology
Fetus / physiology*
Gestational Age*
Heart Rate / physiology
Hydrogen-Ion Concentration
Lung / physiology*
Movement / physiology
Respiratory Mechanics / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Leonurus sibiricus induces nitric oxide and tumor necrosis factor-alpha in mouse peritoneal macropha...
Next Document:  Chemical sympathetic denervation, suppression of myocardial transient outward potassium current, and...