Document Detail


Pulmonary feedback and gestational age-dependent regulation of fetal breathing movements.
MedLine Citation:
PMID:  18841174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal lung development requires fetal breathing movements (FBM). To investigate the dependence of FBM on feedback originating from the lung, we hypothesized that pneumonectomy stimulates FBM. Time-dated fetal sheep underwent bilateral pneumonectomy, unilateral pneumonectomy, or sham surgery at 125-130 days gestation. The incidence of FBM decreased in sham-operated fetuses at 142 days versus 130 days (p = 0.013), but was unchanged across all gestational ages in bilaterally pneumonectomized fetuses (p > or = 0.52). In unilaterally pneumonectomized fetuses, the incidence of FBM remained unchanged until 139 days and was higher than that of the bilaterally pneumonectomized fetuses at 130-136 days gestation (p < or = 0.03). The amplitude of integrated diaphragmatic electromyographic activity (integralEMG(di)) and total respiratory output (frequency of breathing x integralEMG(di)) were lower in pneumonectomized fetuses versus sham-operated fetuses at later gestational ages (p < 0.05). These decreases in integralEMG(di) and total respiratory output were most pronounced at 142 days in bilaterally pneumonectomized fetuses versus sham-operated fetuses (p = 0.006 and 0.016, respectively). Low-voltage electrocortical activity (ECoG) increased, and high-voltage ECoG decreased, in unilaterally pneumonectomized fetuses compared with sham-operated fetuses (p = 0.04). In conclusion, we provide new evidence that feedback from the fetal lung modulates the incidence and various components of phrenic nerve output, suggesting a positive feedback mechanism between FBM and lung development.
Authors:
Shabih U Hasan; Baikunth Bharadwaj; John E Remmers; Avni Patel; Anita Rigaux; Jennifer Schneider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  86     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  691-9     Citation Subset:  IM    
Affiliation:
Departments of Pediatrics, Physiology and Surgery, Institute of Maternal and Child Health, Faculty of Medicine, Health Sciences Centre, 3330 Hospital Drive NW, University of Calgary, Calgary, AB T2N4N1, Canada. hasans@ucalgary.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Blood Gas Analysis
Blood Pressure / physiology
Electroencephalography
Electromyography
Feedback
Female
Fetus / physiology*
Gestational Age*
Heart Rate / physiology
Hydrogen-Ion Concentration
Lung / physiology*
Movement / physiology
Pneumonectomy
Pregnancy
Respiratory Mechanics / physiology*
Sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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