Document Detail


Pulmonary epithelial lining fluid concentrations after use of systemic amphotericin B lipid formulations.
MedLine Citation:
PMID:  19704134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amphotericin B (AMB) concentrations were determined in pulmonary epithelial lining fluid (ELF) of 44 critically ill patients, who were receiving treatment with liposomal AMB (LAMB) (n = 11), AMB colloidal dispersion (ABCD) (n = 28), or AMB lipid complex (ABLC) (n = 5). Mean AMB levels (+/- standard errors of the means) in ELF amounted to 1.60 +/- 0.58, 0.38 +/- 0.07, and 1.29 +/- 0.71 microg/ml in LAMB-, ABCD-, and ABLC-treated patients, respectively (differences are not significant).
Authors:
Stefan Weiler; Gerda Falkensammer; Angelika Hammerer-Lercher; Markus Anliker; Helene Vogelsinger; Michael Joannidis; Stefan Dunzendorfer; Markus Stein; Romuald Bellmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-24
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  53     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-08     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4934-7     Citation Subset:  IM    
Affiliation:
Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amphotericin B / administration & dosage,  pharmacokinetics*
Antifungal Agents / pharmacokinetics*
Epithelium / metabolism
Female
Humans
Lung / metabolism*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B
Comments/Corrections

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