Document Detail

Pulmonary elastin synthesis and deposition in developing and mature sheep: effects of intrauterine growth restriction.
MedLine Citation:
PMID:  15204831     Owner:  NLM     Status:  MEDLINE    
Hypoxia and nutrient restriction during gestation restrict fetal growth and alter lung development. As elastin is intimately involved in lung development, our aim was to assess pulmonary elastin synthesis and deposition following intrauterine growth restriction (IUGR) induced by umbilicoplacental embolization (UPE). Pulmonary tropoelastin expression and elastin content were examined at 128 days (5 days UPE) and 140 days (20 days UPE) of the 147- days gestation and at 8 weeks and 2.3 years after birth (both approximately 27 days UPE) in sheep. UPE induced hypoxemia, hypoglycemia, and fetal growth restriction but did not affect pulmonary tropoelastin mRNA levels or elastin deposition at any age; furthermore, elastin content was unaltered apart from being lower at 140 days. The authors conclude that hypoxemia and undernutrition associated with IUGR do not affect elastin synthesis and deposition in fetal lungs; alterations in lung structure following IUGR must have other causes.
Megan L Cock; Belinda J Joyce; Stuart B Hooper; Megan J Wallace; Robert Gagnon; Robert A Brace; Samantha Louey; Richard Harding
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental lung research     Volume:  30     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-06-18     Completed Date:  2005-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-18     Citation Subset:  IM    
Fetal and Neonatal Research Group, Department of Physiology, Monash University, Clayton, Victoria, Australia.
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MeSH Terms
Balloon Occlusion
Elastin / biosynthesis*
Fetal Growth Retardation / embryology*,  metabolism*
Gestational Age
Lung / embryology*,  metabolism*
Placenta / blood supply
RNA, Messenger / genetics,  metabolism
Sheep / embryology*,  metabolism*
Tropoelastin / genetics
Reg. No./Substance:
0/RNA, Messenger; 0/Tropoelastin; 9007-58-3/Elastin

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