Document Detail

Pulmonary edema: physiologic approaches to management.
MedLine Citation:
PMID:  738094     Owner:  NLM     Status:  MEDLINE    
The integrity of the normal endothelial barrier is responsible for two of the three major safety factors preventing pulmonary edema. This is why edema due to increased pressure is usually not as severe as edema due to increased permeability. Management ought to follow sound physiologic principles. These principles are to lower microvascular hydrostatic pressure and to provide adequate supportive therapy. Positive end-expiratory pressure may improve arterial oxygen transport, but there is no evidence that it improves the balance of pulmonary fluid in edema. Raising the microvascular protein osmotic pressure may be beneficial in edema due to increased pressure but has no demonstrated rationale in edema due to increased permeability.
N C Staub
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  74     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Proteins / metabolism
Capillary Permeability
Oxygen Consumption
Pulmonary Circulation
Pulmonary Edema / etiology,  physiopathology,  therapy*
Reg. No./Substance:
0/Blood Proteins

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