Document Detail

Pulmonary edema complicating continuous intravenous prostacyclin in pulmonary capillary hemangiomatosis.
MedLine Citation:
PMID:  9603154     Owner:  NLM     Status:  MEDLINE    
Continuous intravenous epoprostenol (prostacyclin) produces hemodynamic and symptomatic responses and improves survival in patients with severe primary pulmonary hypertension refractory to conventional medical therapy. However, it has been recently shown that short-term infusion of epoprostenol can produce pulmonary edema in pulmonary veno-occlusive disease, presumably because of increased pulmonary perfusion in the presence of downstream vascular obstruction. We describe two additional cases of pulmonary edema complicating continuous intravenous epoprostenol in patients displaying severe pulmonary hypertension and pulmonary capillary hemangiomatosis, a rare condition characterized by the proliferation of thin-walled microvessels in the alveolar walls. This report indicates that epoprostenol therapy should not be used in patients with severe pulmonary hypertension secondary to pulmonary capillary hemangiomatosis.
M Humbert; S Maître; F Capron; B Rain; D Musset; G Simonneau
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  157     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-16     Completed Date:  1998-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1681-5     Citation Subset:  AIM; IM    
Service de Pneumologie et Réanimation Respiratoire, d'Anatomie Pathologique et de Radiologie, Hôpital Antoine Béclère, Clamart, France.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  adverse effects*
Epoprostenol / administration & dosage,  adverse effects*
Hemangioma, Capillary / complications*,  pathology
Hypertension, Pulmonary / drug therapy*,  etiology
Infusions, Intravenous
Lung / radiography
Lung Neoplasms / complications*,  pathology
Pulmonary Edema / chemically induced*,  radiography
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antihypertensive Agents; 35121-78-9/Epoprostenol

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