Document Detail


Pulmonary distribution of lucinactant and poractant alfa and their peridosing hemodynamic effects in a preterm lamb model of respiratory distress syndrome.
MedLine Citation:
PMID:  20531255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tracheal instillation of surfactant to premature newborns improves their survivability but may transiently obstruct airways resulting in undesirable acute effects on cerebral blood flow (CBF) and oxygenation. The acute peridosing hemodynamic effects of surfactant administration may be avoided by minimizing the volume of surfactant administered, but smaller surfactant volumes may also result in less even distribution of surfactant throughout the lung. These experiments were undertaken to compare responses to two surfactants with different dose volumes (porcine-derived poractant alfa, 2.5 mL/kg vs peptide-based synthetic lucinactant, 5.8 mL/kg) given to newly delivered lambs at 85% gestation. Both surfactants resulted in similar improvements in blood gas values, a doubling of dynamic compliance, increases in brain tissue oxygen tension, and stable blood pressure with no significant change in CBF. Distribution of surfactant throughout the lungs was more uniform with lucinactant than poractant alfa when assessed by labeled microspheres. We conclude that improvements in lung mechanics, gas exchange, and changes in CBF are comparable for a porcine-derived and peptide-containing synthetic surfactant, despite instilled volumes differing by 2-fold. Intrapulmonary distribution of surfactant is more uniform after a larger volume is instilled.
Authors:
Michael H Terry; T A Merritt; Benjamin Harding; Hobe Schroeder; Jeanette Merrill-Henry; Jan Mazela; Timothy J Gregory; Robert Segal; Gordon G Power; Arlin B Blood
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2010-11-30     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Affiliation:
Department of Respiratory Care, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biological Agents / pharmacology*,  therapeutic use
Blood Gas Analysis
Blood Pressure / drug effects
Brain / metabolism
Disease Models, Animal*
Dose-Response Relationship, Drug
Drug Combinations
Fatty Alcohols / pharmacology*,  therapeutic use
Humans
Infant, Newborn
Lung / drug effects,  physiology
Microspheres
Oxygen / metabolism
Phosphatidylglycerols / pharmacology*,  therapeutic use
Phospholipids / pharmacology*,  therapeutic use
Proteins / pharmacology*,  therapeutic use
Pulmonary Surfactants / pharmacology*,  therapeutic use
Respiratory Distress Syndrome, Newborn / drug therapy,  metabolism*
Sheep
Chemical
Reg. No./Substance:
0/Biological Agents; 0/Drug Combinations; 0/Fatty Alcohols; 0/Phosphatidylglycerols; 0/Phospholipids; 0/Proteins; 0/Pulmonary Surfactants; 0/lucinactant; 7782-44-7/Oxygen; KE3U2023NP/poractant alfa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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