Document Detail

Pulmonary disease as a complication of chlorozotocin chemotherapy.
MedLine Citation:
PMID:  6453644     Owner:  NLM     Status:  MEDLINE    
Two of 200 patients treated with chlorozotocin have evidenced interstitial pulmonary disease. The cumulative doses of chlorozotocin were 480 and 670 mg/m2 when symptoms developed. Pulmonary function tests in both patients showed impaired diffusion, and an alveolar-arterial gradient which worsened with exercise. Open-lung biopsy in one patient showed typical interstitial inflammation and early fibrosis, and excluded lymphangitic spread of tumor. Discontinuation of chlorozotocin resulted in either improvement or stabilization of the pulmonary disease.
J D Ahlgren; F P Smith; D M Kerwin; B I Sikic; J H Weiner; P S Schein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer treatment reports     Volume:  65     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:    1981 Mar-Apr
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-9     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / adverse effects*
Lung Diseases / chemically induced*,  pathology
Lung Volume Measurements
Neoplasms / complications,  drug therapy*
Pulmonary Fibrosis / chemically induced
Streptozocin / adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Antineoplastic Agents; 18883-66-4/Streptozocin; 54749-90-5/chlorozotocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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