| Pulmonary diffusional screening and the scaling laws of mammalian metabolic rates. | |
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MedLine Citation:
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PMID: 22304124 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Theoretical considerations suggest that the mammalian metabolic rate is linearly proportional to the surface areas of mitochondria, capillary, and alveolar membranes. However, the scaling exponents of these surface areas to the mammals' body mass (approximately 0.9-1) are higher than exponents of the resting metabolic rate (RMR) to body mass (approximately 0.75), although similar to the one of exercise metabolic rate (EMR); the underlying physiological cause of this mismatch remains unclear. The analysis presented here shows that discrepancies between the scaling exponents of RMR and the relevant surface areas may originate from, at least for the system of alveolar membranes in mammalian lungs, the facts that (i) not all of the surface area is involved in the gas exchange and (ii) that larger mammals host a smaller effective surface area that participates in the material exchange rate. A result of these facts is that lung surface areas unused at rest are activated under heavy breathing conditions (e.g., exercise), wherein larger mammals support larger activated surface areas that provide a higher capability to increase the gas-exchange rate, allowing for mammals to meet, for example, the high energetic demands of foraging and predation. |
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Authors:
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Chen Hou; Michael Mayo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
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Title: Physical review. E, Statistical, nonlinear, and soft matter physics Volume: 84 ISSN: 1550-2376 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136452 Medline TA: Phys Rev E Stat Nonlin Soft Matter Phys Country: - |
Other Details:
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Languages: ENG Pagination: 061915 Citation Subset: - |
Affiliation:
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Department of Biological Sciences, Missouri University of Science and Technology, Rolla, Missouri 65409, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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