| Pulmonary diffusion capacities for O2 and CO measured by a rebreathing technique. | |
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MedLine Citation:
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PMID: 7319894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary diffusion capacity (D) for O2 and CO was determined from alveolar-mixed venous equilibration kinetics of 16O2, 18O2, and C18O measured during rebreathing by mass spectrometry. During the rebreathing maneuver (15 s) the ventilation was extremely high (about 100 1 X min-1) and PO2 and PCO2 in lung gas were close to their mixed venous values (aveolar hypoxia and hypercapnia). The following mean values (+/- SD) were found in six healthy males (20-33 yr) sitting on a bicycle ergometer (in ml X min-1 X Torr-1): 1) without work load, D18O2 = 54 +/- 10, Dc18O = 47 +/- 11; 2) with the highest work load tested (150 W, O2 uptake 2.1 l X min-1), D18O2 = 62 +/- 12, Dc18O = 54 +/- 8. The ratio D16O2/D18O2 averaged 1.07. The ratio D18O2/Dc18O, averaging 1.2 at rest and at all exercise levels, was close to the estimated O2/CO ratio of Krogh's diffusion constants for tissue and, therefore, was in agreement with the diffusion limitation model. An analysis of the various factors affecting the DO2/DCO ratio does not allow to reliably assess the role of diffusion in red blood cells and reaction with hemoglobin in limiting alveolar-capillary O2 transfer. |
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Authors:
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M Meyer; P Scheid; G Riepl; H J Wagner; J Piiper |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 51 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-03-22 Completed Date: 1982-03-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1643-50 Citation Subset: IM; S |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Monoxide / metabolism* Humans Male Oxygen Consumption* Oxygen Isotopes / diagnostic use Pulmonary Diffusing Capacity* Solubility |
| Chemical | |
Reg. No./Substance:
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0/Oxygen Isotopes; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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