Document Detail

Pulmonary diffusion capacities for O2 and CO measured by a rebreathing technique.
MedLine Citation:
PMID:  7319894     Owner:  NLM     Status:  MEDLINE    
Pulmonary diffusion capacity (D) for O2 and CO was determined from alveolar-mixed venous equilibration kinetics of 16O2, 18O2, and C18O measured during rebreathing by mass spectrometry. During the rebreathing maneuver (15 s) the ventilation was extremely high (about 100 1 X min-1) and PO2 and PCO2 in lung gas were close to their mixed venous values (aveolar hypoxia and hypercapnia). The following mean values (+/- SD) were found in six healthy males (20-33 yr) sitting on a bicycle ergometer (in ml X min-1 X Torr-1): 1) without work load, D18O2 = 54 +/- 10, Dc18O = 47 +/- 11; 2) with the highest work load tested (150 W, O2 uptake 2.1 l X min-1), D18O2 = 62 +/- 12, Dc18O = 54 +/- 8. The ratio D16O2/D18O2 averaged 1.07. The ratio D18O2/Dc18O, averaging 1.2 at rest and at all exercise levels, was close to the estimated O2/CO ratio of Krogh's diffusion constants for tissue and, therefore, was in agreement with the diffusion limitation model. An analysis of the various factors affecting the DO2/DCO ratio does not allow to reliably assess the role of diffusion in red blood cells and reaction with hemoglobin in limiting alveolar-capillary O2 transfer.
M Meyer; P Scheid; G Riepl; H J Wagner; J Piiper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  51     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1643-50     Citation Subset:  IM; S    
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MeSH Terms
Carbon Monoxide / metabolism*
Oxygen Consumption*
Oxygen Isotopes / diagnostic use
Pulmonary Diffusing Capacity*
Reg. No./Substance:
0/Oxygen Isotopes; 630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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