Document Detail

Pulmonary diffusion and aerobic capacity: is there a relation? Does obesity matter?
MedLine Citation:
PMID:  19912149     Owner:  NLM     Status:  MEDLINE    
AIM: We sought to determine whether pulmonary diffusing capacity for nitric oxide (DLNO), carbon monoxide (DLCO) and pulmonary capillary blood volume (Vc) at rest predict peak aerobic capacity (VO2peak), and if so, to discern which measure predicts better.
METHODS: Thirty-five individuals with extreme obesity (body mass index or BMI = 50 +/- 8 kg m((-2)) and 26 fit, non-obese subjects (BMI = 23 +/- 2 kg m((-2)) participated. DLNO and DLCO at rest were first measured. Then, subjects performed a graded exercise test on a cycle ergometer to determine (VO2peak). Multivariate regression was used to assess relations in the data.
RESULTS: Findings indicate that (i) pulmonary diffusion at rest predicts (VO2peak) in the fit and obese when measured with DLNO, but only in the fit when measured with DLCO; (ii) the observed relation between pulmonary diffusion at rest and (VO2peak) is different in the fit and obese; (iii) DLNO explains (VO2peak) better than DLCO or Vc. The findings imply the following reference equations for DLNO: (VO2peak) (mL kg(-1) min(-1)) = 6.81 + 0.27 x DLNO for fit individuals; (VO2peak) (mL kg(-1) min(-1)) = 6.81 + 0.06 x DLNO, for obese individuals (in both groups, adjusted R(2 )=( )0.92; RMSE = 5.58).
CONCLUSION: Pulmonary diffusion at rest predicts (VO2peak), although a relation exists for obese subjects only when DLNO is used, and the magnitude of the relation depends on gender when either DLCO or Vc is used. We recommend DLNO as a measure of pulmonary diffusion, both for its ease of collection as well as its tighter relation with (VO2peak).
G S Zavorsky; B Wilson; J K Harris; D J Kim; F Carli; N E Mayo
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Publication Detail:
Type:  Journal Article     Date:  2009-11-13
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  198     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-08-10     Revised Date:  2012-03-12    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  499-507     Citation Subset:  IM    
Department of Obstetrics, Gynecology and Women's Health, Saint Mary's Health Center, Saint Louis University, MO 63117, USA. <>
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MeSH Terms
Carbon Monoxide / pharmacology*
Exercise / physiology*
Exercise Test
Exercise Tolerance
Middle Aged
Nitric Oxide / physiology
Obesity / chemically induced,  physiopathology*
Oxygen / metabolism*
Oxygen Consumption / physiology
Physical Exertion / physiology
Pulmonary Alveoli / physiology*
Pulmonary Diffusing Capacity / drug effects,  physiology*
Respiratory Function Tests / methods
Reg. No./Substance:
10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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