| Pulmonary diffusion and aerobic capacity: is there a relation? Does obesity matter? | |
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MedLine Citation:
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PMID: 19912149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: We sought to determine whether pulmonary diffusing capacity for nitric oxide (DLNO), carbon monoxide (DLCO) and pulmonary capillary blood volume (Vc) at rest predict peak aerobic capacity (VO2peak), and if so, to discern which measure predicts better. METHODS: Thirty-five individuals with extreme obesity (body mass index or BMI = 50 +/- 8 kg m((-2)) and 26 fit, non-obese subjects (BMI = 23 +/- 2 kg m((-2)) participated. DLNO and DLCO at rest were first measured. Then, subjects performed a graded exercise test on a cycle ergometer to determine (VO2peak). Multivariate regression was used to assess relations in the data. RESULTS: Findings indicate that (i) pulmonary diffusion at rest predicts (VO2peak) in the fit and obese when measured with DLNO, but only in the fit when measured with DLCO; (ii) the observed relation between pulmonary diffusion at rest and (VO2peak) is different in the fit and obese; (iii) DLNO explains (VO2peak) better than DLCO or Vc. The findings imply the following reference equations for DLNO: (VO2peak) (mL kg(-1) min(-1)) = 6.81 + 0.27 x DLNO for fit individuals; (VO2peak) (mL kg(-1) min(-1)) = 6.81 + 0.06 x DLNO, for obese individuals (in both groups, adjusted R(2 )=( )0.92; RMSE = 5.58). CONCLUSION: Pulmonary diffusion at rest predicts (VO2peak), although a relation exists for obese subjects only when DLNO is used, and the magnitude of the relation depends on gender when either DLCO or Vc is used. We recommend DLNO as a measure of pulmonary diffusion, both for its ease of collection as well as its tighter relation with (VO2peak). |
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Authors:
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G S Zavorsky; B Wilson; J K Harris; D J Kim; F Carli; N E Mayo |
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Publication Detail:
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Type: Journal Article Date: 2009-11-13 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: 198 ISSN: 1748-1716 ISO Abbreviation: Acta Physiol (Oxf) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-08-10 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 499-507 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Women's Health, Saint Mary's Health Center, Saint Louis University, MO 63117, USA. zavorsky@slu.edu <zavorsky@slu.edu> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Monoxide / pharmacology* Exercise / physiology* Exercise Test Exercise Tolerance Humans Male Middle Aged Nitric Oxide / physiology Obesity / chemically induced, physiopathology* Oxygen / metabolism* Oxygen Consumption / physiology Physical Exertion / physiology Pulmonary Alveoli / physiology* Pulmonary Diffusing Capacity / drug effects, physiology* Respiratory Function Tests / methods |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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