Document Detail

Pulmonary crystal-storing histiocytoma.
MedLine Citation:
PMID:  16119991     Owner:  NLM     Status:  MEDLINE    
We describe the case of a 50-year-old woman with a lung tumor composed of crystal-storing histiocytes. These cells and associated plasma cells failed to show clonal light chain restriction, and the patient had no associated hematologic disorder. The differential diagnosis included crystal-storing histiocytosis, characterized by accumulation of crystallized immunoglobulins, a rare manifestation of monoclonal gammopathies/plasma cell dyscrasias. Crystal-laden histiocytes have previously been described in many organs. Four reports have described crystal-storing histiocytosis in the lung, always associated with a lymphoproliferative disorder. The present patient, 1 other case from our archive, and 1 case reported in the literature, all without an association with lymphoproliferative disorder, make a full description and definition of this lesion appropriate. The morphology, immunohistochemical profile, and electron microscopic features are described herein, and the term pulmonary crystal-storing histiocytoma is proposed. A practical algorithm is presented for the assessment of solitary lung masses composed of large histiocytic cells.
Diana N Ionescu; Diane M Pierson; Gefei Qing; Maomi Li; Thomas V Colby; Kevin O Leslie
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  129     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2005-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1159-63     Citation Subset:  AIM; IM    
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
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MeSH Terms
Diagnosis, Differential
Histiocytes / chemistry,  pathology*,  ultrastructure
Histiocytoma / chemistry,  pathology*,  surgery
Histiocytosis / diagnosis
Immunoenzyme Techniques
Immunoglobulins / chemistry,  ultrastructure
Lung Neoplasms / chemistry,  pathology*,  surgery
Lysosomes / ultrastructure
Middle Aged
Plasma Cells
Tumor Markers, Biological
Reg. No./Substance:
0/Immunoglobulins; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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