Document Detail

Pulmonary compliance: early assessment of evolving lung injury after onset of sepsis.
MedLine Citation:
PMID:  2077027     Owner:  NLM     Status:  MEDLINE    
We compared the sensitivity of dynamic (Cdyn) and static lung compliance (CL) with indicators of permeability injury in a model of septic porcine adult respiratory distress syndrome. Two groups of anesthetized ventilated swine (15-25 kg) were studied. Septic animals (Ps, n = 13) received Pseudomonas aeruginosa intravenously for 1 h, which resulted in severe adult respiratory distress syndrome. Controls (C, n = 13) received 0.9% NaCl. Cdyn, CL, bronchoalveolar lavage for protein estimation, and thermal cardiogreen extravascular lung water (EVLW) measurements were performed in seven C and eight Ps animals. Six C and five Ps animals underwent gamma camera measurement of lung-to-heart ratio (slope index) of 99Tc-labeled human serum albumin. Both Cdyn and CL decreased significantly (P less than 0.01) at 30 min and thereafter in Ps vs. C. EVLW, slope index, and bronchoalveolar protein content increased significantly (P less than 0.05) in Ps vs. C at 120, 150, and 300 min, respectively. Cdyn and CL decreased well before onset of permeability injury. These early changes may be due to release of vasoactive mediators and sequestration of neutrophils in the pulmonary capillaries and later to increases in EVLW. Measurement of Cdyn and CL represents an early means of assessing evolving lung injury in this acute septic porcine model.
K Byrne; K R Cooper; P D Carey; A Berlin; T D Sielaff; C R Blocher; J K Jenkins; B J Fisher; J I Hirsch; J L Tatum
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  69     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-22     Completed Date:  1991-04-22     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2290-5     Citation Subset:  IM    
Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0519.
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MeSH Terms
Disease Models, Animal
Lung / physiopathology*
Lung Compliance*
Pseudomonas Infections / physiopathology*
Reference Values
Respiratory Distress Syndrome, Adult / physiopathology*
Sepsis / physiopathology*
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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