Document Detail


Pulmonary clearance of Moraxella catarrhalis in an animal model.
MedLine Citation:
PMID:  1532405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The virulence mechanisms of Moraxella catarrhalis that are involved in producing pulmonary infection are unknown. A well-characterized murine model was used to study the pulmonary clearance of M. catarrhalis and analyze the histopathologic changes and the role of phagocytic cells in the infected lungs. Ten strains of M. catarrhalis from various isolation sites were evaluated for their ability to resist pulmonary clearance. The rates of clearance of these strains, based on the percentage of the original inoculum remaining at 6 h after challenge, varied considerably. Histopathologic examination of lungs infected with 2 strains that exhibited very different clearance rates revealed similar pathologic responses. Analysis of the phagocytic cell response to these 2 strains revealed significant alveolar recruitment of granulocytes at 3, 6, and 24 h after bacterial challenge. However, granulocyte recruitment in response to strain B22, which was cleared readily, was significantly greater than to strain 035E, which resisted pulmonary clearance. This model system should facilitate investigation of the molecular basis of the interaction between M. catarrhalis and the lower respiratory tract.
Authors:
M Unhanand; I Maciver; O Ramilo; O Arencibia-Mireles; J C Argyle; G H McCracken; E J Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  165     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-24     Completed Date:  1992-04-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  644-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Bacterial / analysis
Bacterial Outer Membrane Proteins / analysis
Bronchoalveolar Lavage Fluid / cytology,  microbiology
Cell Count
Disease Models, Animal
Electrophoresis, Polyacrylamide Gel
Female
Lipopolysaccharides / analysis
Lung / immunology,  microbiology*,  pathology
Macrophages, Alveolar / immunology
Mice
Mice, Inbred BALB C
Moraxella (Branhamella) catarrhalis / chemistry,  immunology,  physiology*
Neisseriaceae Infections / immunology,  microbiology*
Neutrophils / immunology
Phagocytosis
Phenotype
Regression Analysis
Specific Pathogen-Free Organisms
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Bacterial Outer Membrane Proteins; 0/Lipopolysaccharides; 0/lipid-linked oligosaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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