| Pulmonary and circulatory function in preterm lambs treated with hydrocortisone in utero. | |
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MedLine Citation:
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PMID: 737247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the in utero intravenous administration of hydrocortisone on postnatal lung function and pulmonary and systemic hemodynamics were studied in preterm fetal lambs and compared with those of non-treated animals of similar gestational ages. The results indicate that steroid-induced changes in lung pressure volume curves, although statistically significant, did not render the pretreated fetuses capable of surviving without ventilatory assistance. In addition, the ductus arteriosus in the steroid-treated lambs at 2 h of age was functionally closed or constricted regardless of gestational age. In contrast, in the untreated lambs the ductus arteriosus was widely patent and, especially in lambs of less than 120 days gestation, there was invariably a large left-to-right ductal shunt. |
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Authors:
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D W Thibeault; G C Emmanouilides; M E Dodge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the neonate Volume: 34 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1978 |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 238-47 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn* Ductus Arteriosus / drug effects, embryology Female Gestational Age Hemodynamics / drug effects* Hydrocortisone / administration & dosage, pharmacology* Injections, Intravenous Lung / embryology Maternal-Fetal Exchange Pregnancy Pressure Pulmonary Circulation / drug effects* Respiration / drug effects* Sheep |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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