Document Detail

Pulmonary and chest wall mechanics in anesthetized paralyzed humans.
MedLine Citation:
PMID:  1885455     Owner:  NLM     Status:  MEDLINE    
Pulmonary and chest wall mechanics were studied in 18 anesthetized paralyzed supine humans by use of the technique of rapid airway occlusion during constant-flow inflation. Analysis of the changes in transpulmonary pressure after flow interruption allowed partitioning of the overall resistance of the lung (RL) into two compartments, one (Rint,L) reflecting airway resistance and the other (delta RL) representing the viscoelastic properties of the pulmonary tissues. Similar analysis of the changes in esophageal pressure indicates that chest wall resistance (RW) was due entirely to the viscoelastic properties of the chest wall tissues (delta RW = RW). In line with previous measurements of airway resistance, Rint,L increased with increasing flow and decreased with increasing volume. The opposite was true for both delta RL and delta RW. This behavior was interpreted in terms of a viscoelastic model that allowed computation of the viscoelastic constants of the lung and chest wall. This model also accounts for frequency, volume, and flow dependence of elastance of the lung and chest wall. Static and dynamic elastances, as well as delta R, were higher for the lung than for the chest wall.
E D'Angelo; F M Robatto; E Calderini; M Tavola; D Bono; G Torri; J Milic-Emili
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  70     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2602-10     Citation Subset:  IM    
Istituto di Fisiologia Umana, Università di Milano, Italy.
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MeSH Terms
Airway Resistance / physiology
Lung / physiology
Lung Compliance / physiology
Paralysis / physiopathology
Pulmonary Ventilation / physiology
Respiratory Mechanics / physiology*
Thorax / physiology

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