| Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats. | |
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MedLine Citation:
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PMID: 9820679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the biological plausibility of the adverse health effects of ambient particulate matter (PM), we have studied the cardio-pulmonary effects of PM in an animal model of pulmonary hypertension. Normal and monocrotaline-treated rats were exposed, nose-only, for 3 h to filtered air or concentrated ambient PM. At 3 h--but not 24 h--post-exposure, the percentage of neutrophils in peripheral blood was significantly elevated in PM-exposed animals while the percentage of lymphocytes was decreased with no change in white blood cell counts. These changes in white blood cell differential occurred in both normal and monocrotaline-treated animals. Small, but consistent changes in heart rate, but not core temperature, were observed after exposure to concentrated ambient PM. Pulmonary injury, as evidenced by increased protein levels in lavage fluid, occurred only in monocrotaline-treated animals exposed to > 360 microg/m3 PM. The observed pattern of hematological and cardiac changes suggests an activation of the sympathetic stress response. |
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Authors:
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T Gordon; C Nadziejko; R Schlesinger; L C Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology letters Volume: 96-97 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-12-01 Completed Date: 1998-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 285-8 Citation Subset: IM |
Affiliation:
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Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA. gordont@charlotte.med.nyu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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toxicity* Air Pollution, Indoor / adverse effects* Animals Body Temperature / drug effects Cardiovascular System / drug effects* Disease Models, Animal Heart Rate / drug effects Hypertension, Pulmonary / chemically induced, physiopathology Leukocyte Count / drug effects Lung / drug effects* Monocrotaline Particle Size Rats Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 315-22-0/Monocrotaline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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