Document Detail

Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats.
MedLine Citation:
PMID:  9820679     Owner:  NLM     Status:  MEDLINE    
To examine the biological plausibility of the adverse health effects of ambient particulate matter (PM), we have studied the cardio-pulmonary effects of PM in an animal model of pulmonary hypertension. Normal and monocrotaline-treated rats were exposed, nose-only, for 3 h to filtered air or concentrated ambient PM. At 3 h--but not 24 h--post-exposure, the percentage of neutrophils in peripheral blood was significantly elevated in PM-exposed animals while the percentage of lymphocytes was decreased with no change in white blood cell counts. These changes in white blood cell differential occurred in both normal and monocrotaline-treated animals. Small, but consistent changes in heart rate, but not core temperature, were observed after exposure to concentrated ambient PM. Pulmonary injury, as evidenced by increased protein levels in lavage fluid, occurred only in monocrotaline-treated animals exposed to > 360 microg/m3 PM. The observed pattern of hematological and cardiac changes suggests an activation of the sympathetic stress response.
T Gordon; C Nadziejko; R Schlesinger; L C Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  96-97     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-01     Completed Date:  1998-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  285-8     Citation Subset:  IM    
Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA.
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MeSH Terms
Air Pollutants / toxicity*
Air Pollution, Indoor / adverse effects*
Body Temperature / drug effects
Cardiovascular System / drug effects*
Disease Models, Animal
Heart Rate / drug effects
Hypertension, Pulmonary / chemically induced,  physiopathology
Leukocyte Count / drug effects
Lung / drug effects*
Particle Size
Reproducibility of Results
Reg. No./Substance:
0/Air Pollutants; 315-22-0/Monocrotaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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