Document Detail

Pulmonary blood flow regulation: influence of positive pressure ventilation.
MedLine Citation:
PMID:  8904016     Owner:  NLM     Status:  MEDLINE    
Positive pressure ventilation with PEEP has been reported to reduce hypoxic pulmonary vasoconstriction (HPV) and thus increase venous admixture. This effect was investigated in six chronically instrumented unanesthetized healthy sheep. The change in left pulmonary arterial blood flow (Qlpa, ultrasonic transit time) in response to unilateral lung hypoxia (10 min of N2 alternately to the left (LLH) and right lung (RLH) was evaluated during mechanical ventilation with and without PEEP of 10 cm H2O in comparison to spontaneous breathing. In the spontaneously breathing animal and during mechanical ventilation without PEEP, Qlpa decreased during LLH from 30% to 16% of cardiac index, during RLH it increased to 51%. With 10 cm H2O of PEEP, Qlpa showed an identical reaction to hypoxia both in the left and right lung. It is concluded that mechanical ventilation and PEEP up to 10 cm H2O does not interfere with pulmonary blood flow regulation to hypoxia.
J L Theissen; S R Fischer; L D Traber; D L Traber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  102     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  251-60     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care Medicine, Wesfalische Wilhelms-Universitat, Munster, Germany.
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MeSH Terms
Anoxia / metabolism
Blood Gas Analysis
Carbon Dioxide / blood
Hydrogen-Ion Concentration
Nitrogen / pharmacology
Oxygen / blood
Positive-Pressure Respiration*
Pulmonary Circulation / physiology*
Respiratory Mechanics
Sheep / metabolism,  physiology
Vasoconstriction / physiology
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7727-37-9/Nitrogen; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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