Document Detail

Pulmonary blood flow reduction by prostaglandin F2 alpha and pulmonary artery balloon manipulation during one-lung ventilation in dogs.
MedLine Citation:
PMID:  3083629     Owner:  NLM     Status:  MEDLINE    
The purpose of this experimental study was to compare two methods of pulmonary blood flow manipulation during one-lung ventilation (OLV), either reducing pulmonary blood flow to the non-ventilated lung by inflation of a pulmonary artery catheter balloon (PAB) or by infusion of prostaglandin F2 alpha (PGF2 alpha). Seven anaesthetized dogs were intubated with a Kottmeier endobronchial tube and ventilated with 66% O2. Systemic and pulmonary pressures and blood gases, cardiac output and airway pressure were measured, and the venous admixture (QSP/QT) was calculated. During two-lung ventilation (TLV) Pao2 was 43.6 +/- 1.9 kPa (mean +/- s.d.) and (QSP/QT) was 11 +/- 3%. OLV reduced Pao2 to 12.1 +/- 1.6 kPa (P less than or equal to 0.001) and increased QSP/QT to 40 +/- 4% (P less than or equal to 0.001). Mean pulmonary artery pressure and airway pressure increased. PAB inflation caused an increase in Pao2 to 19.9 +/- 2.9 kPa (P less than or equal to 0.02) and a decrease in QSP/QT to 27 +/- 6% (P less than or equal to 0.001). PGF2 alpha infusion (1.2 micrograms kg-1 min-1) into the pulmonary artery of the non-ventilated lung increased Pao2 to 22.4 +/- 3.3 kPa (P less than or equal to 0.001) and decreased QSP/QT to 25 +/- 4 (P less than or equal to 0.001). PGF2 alpha infusion resulted in a small increase in mean systemic and pulmonary artery pressures. During the infusion of 1.2 micrograms kg-1 min-1 of PGF2 alpha no signs of bronchoconstriction were observed. PAB inflation and PGF2 alpha infusion were equally effective in improving oxygenation and reducing venous admixture during OLV.(ABSTRACT TRUNCATED AT 250 WORDS)
R Scherer; G Vigfusson; P Lawin
Related Documents :
3191739 - Respiratory alkalosis attenuates thromboxane-induced pulmonary hypertension.
6138119 - Response of pulmonary circulation to oral pirbuterol in chronic airflow obstruction.
8239149 - Endothelin-1 in adult respiratory distress syndrome.
25382969 - The diurnal and nocturnal effects of travoprost in normal-tension glaucoma.
10201049 - Benefit of in-phase chest wall vibration on the pulmonary hemodynamics in patients with...
1763649 - Noninvasive estimation of pulmonary arterial blood pressure in burned patients with acu...
12484959 - Universal scaling in transient creep.
7366909 - Effect of dihydralazine on the fetus in the treatment of maternal hypertension.
12500019 - Temazepam, but not zolpidem, causes orthostatic hypotension in astronauts after spacefl...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  30     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-25     Completed Date:  1986-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  2-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Assisted Circulation
Blood Pressure / drug effects
Carbon Dioxide / analysis
Cardiac Output / drug effects
Heart Rate / drug effects
Partial Pressure
Prostaglandins F / pharmacology*
Pulmonary Artery / physiology*
Pulmonary Circulation / drug effects*
Respiration, Artificial
Vascular Resistance / drug effects
Reg. No./Substance:
0/Prostaglandins F; 124-38-9/Carbon Dioxide; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Long-term cultivation of calf aortic endothelial cells. Demonstration of the production of factor VI...
Next Document:  The effect of intranasally administered nitroglycerin on the blood pressure response to laryngoscopy...