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Pulmonary biosynthesis and metabolism of prostaglandins and related substances.
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MedLine Citation:
PMID:  6428876     Owner:  NLM     Status:  MEDLINE    
On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro, PGI2 is not a substrate for the carrier system. Thus, the transport carrier determines which circulating prostaglandin is inactivated by the pulmonary vascular bed. Also, the lung has a high capacity for forming prostaglandins from arachidonic acid. Considerable differences exist between species in relation to amount and specific prostaglandin formed as determined by incubation of 11C-PGH2 with pulmonary microsomes. The pulmonary biosynthesis and metabolism of these prostaglandins and related substances are discussed.
T E Eling; A I Ally
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  55     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Lung / enzymology,  metabolism*,  ultrastructure
Microsomes / metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Prostaglandins / biosynthesis,  metabolism*,  secretion
Subcellular Fractions / metabolism
Thromboxanes / metabolism
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 0/Thromboxanes; 506-32-1/Arachidonic Acid; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 4 Year: 1984
Volume: 55First Page: 159 Last Page: 168
ID: 1568381
PubMed Id: 6428876

Pulmonary biosynthesis and metabolism of prostaglandins and related substances.
T E Eling
A I Ally

Article Categories:
  • Research Article

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