| Pulmonary artery pressure responses to increased cardiac output in chickens with raised metabolic rate. | |
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MedLine Citation:
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PMID: 20363353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous work has shown remarkable differences in the pressure-flow relations of the pulmonary circulation between birds and mammals. For example several studies suggest that the avian pulmonary blood vessels behave like rigid tubes, very different from the situation in mammalian lung. We therefore speculated that birds would develop high pulmonary artery pressures when the cardiac output was substantially increased during heavy exercise, for example during flight. However because of the technical difficulties of measuring pulmonary artery pressures in flight, the metabolic rate and cardiac output in anesthetized chickens were increased by infusing 2,4 Dinitrophenol (DNP) and the mean pressure was measured by means of a catheter in the pulmonary artery. Although the pulmonary artery pressure rose steadily as cardiac output increased, it remained below the high levels predicted from the previous studies for similar changes in pulmonary blood flow. Furthermore the increase in pressure was less than in mammals where recruitment and distension of pulmonary capillaries are known to occur. The reasons for this unexpected result are not clear. |
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Authors:
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John B West; Zhenxing Fu; Yusu Gu; Harrieth E Wagner; J Austin Carr; Kirk L Peterson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-02 |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 156 ISSN: 1531-4332 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2011-01-25 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 430-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, University of California San Diego, La Jolla CA 92093-0623, USA. jwest@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology* Cardiac Output / physiology* Chickens / physiology* Oxygen Consumption / physiology Physical Conditioning, Animal / physiology Pulmonary Artery / physiology* Pulmonary Circulation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL 60968/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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