| Pulmonary artery pressure--flow plots in hyperoxic and in hypoxic dogs: effects of prostaglandin E1. | |
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MedLine Citation:
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PMID: 3148479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of prostaglandin E1 on mean pulmonary artery pressure (Ppa):cardiac index (Q) relationships were investigated in eight anaesthetized dogs, ventilated in hyperoxia (fraction of inspired oxygen (FiO2) 0.4) and in hypoxia (FiO2 0.1). Cardiac output was increased by opening an arterio-venous femoral bypass or reduced by stepwise inflations of a balloon in the inferior vena cava. Five-point Ppa:Q relationships were found to be linear in all experimental conditions. Hypoxia increased Ppa over the entire range of Q studied (1-5l.min-1.m-2). Prostaglandin E1 0.4 microgram.kg-1.min-1 intravenously decreased hyperoxic Ppa for Q ranging from 3-5 l.min-1.m-2, hypoxic Ppa for Q ranging from 2-5 l.min-1.m-2 and attenuated hypoxia-induced increases in Ppa. These results show that prostaglandin E1 is a pulmonary vasodilator in both hyperoxic and hypoxic conditions. At the dose of 0.4 microgram.kg-1, prostaglandin E1 partially inhibits hypoxic pulmonary vasoconstriction. |
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Authors:
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M Leeman; P Lejeune; C Mélot; R Naeije |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal Volume: 1 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1989-04-28 Completed Date: 1989-04-28 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 711-5 Citation Subset: IM |
Affiliation:
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Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil
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pharmacology* Animals Anoxia / physiopathology* Blood Pressure / drug effects* Carbon Dioxide / pharmacology Cardiac Output / drug effects Dogs Oxygen / blood* Pulmonary Artery / drug effects, physiopathology* Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 745-65-3/Alprostadil; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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