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Pulmonary artery leiomyosarcoma: an unusual cause of shortness of breath.
MedLine Citation:
PMID:  19921308     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
INTRODUCTION: Primary leiomyosarcomas of the pulmonary artery are very rare tumours with 30 cases reported in the English literature. Herein, we report the first case with evidence of a renal metastasis.
MATERIALS AND METHODS: The tumour was discovered at autopsy in a 61-year-old woman who had presented with shortness of breath and chest pain. It was located in the pulmonary trunk with extension into the adjacent pericardial cavity. Separate nodules were found in the pulmonary valve, the left pulmonary artery and the left kidney.
RESULTS: On microscopic examination, the tumour was composed of spindle cells with cigar-shaped nuclei immunoreactive for vimentin, desmin, CD68 and α-smooth muscle actin.
CONCLUSIONS: Primary pulmonary artery leiomyosarcoma is easily confused clinically with pulmonary thromboembolism and most cases are diagnosed post mortem. Most tumours arise in the pulmonary trunk and metastases are only rarely described. The management of patients with this rare tumour depends on early surgical resection and the prognosis is unfavourable.
Authors:
G Flaherty; P McCarthy; G Mortimer
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Publication Detail:
Type:  Journal Article     Date:  2009-11-17
Journal Detail:
Title:  Irish journal of medical science     Volume:  180     ISSN:  1863-4362     ISO Abbreviation:  Ir J Med Sci     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University Hospital, Galway and National University of Ireland, Galway, Ireland, gerard.flaherty@nuigalway.ie.
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