Document Detail

Pulmonary artery and aortic pressure changes during high intensity treadmill exercise in the horse: effect of frusemide and phentolamine.
MedLine Citation:
PMID:  1606935     Owner:  NLM     Status:  MEDLINE    
Intravenous frusemide (1.0 mg/kg bwt) or phentolamine (0.33 mg/kg bwt) was given to 7 horses 1 h before exercise and their effects on pulmonary artery and aortic pressure changes during strenuous exercise were examined. Short-term near-maximal treadmill exercise (10 m/sec, 3 degrees incline) produced increases in heart rate, mean pulmonary artery pressure (PAP), mean aortic pressure (AP), and packed cell volume (PCV). Frusemide did not affect heart rate, PAP or PCV during exercise. Frusemide significantly decreased mean AP by 10 to 15 mmHg during exercise. Phentolamine produced an increase in heart rate relative to control only early in exercise but not during later, more strenuous, exercise. Phentolamine had no statistically significant effect on AP, PAP, or PCV, but a significant reduction was observed between 180 and 230 sec of exercise when PAP and AP were standardised against heart rate. Frusemide did not prevent horses from haemorrhaging during exercise in this study. Treatment with phentolamine did not sufficiently reduce the PAP and AP to test our hypothesis that a reduction in PAP and AP would eliminate EIPH.
B K Erickson; H H Erickson; J R Coffman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Equine veterinary journal     Volume:  24     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-21     Completed Date:  1992-07-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
College of Veterinary Medicine, Kansas State University, Manhattan 66506.
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MeSH Terms
Aorta / physiology
Blood Pressure / drug effects*
Exercise Test / veterinary
Furosemide / pharmacology*
Heart Rate / drug effects
Hematocrit / veterinary
Horses / physiology*
Phentolamine / pharmacology*
Physical Exertion / physiology*
Pulmonary Artery / physiology
Pulmonary Wedge Pressure / drug effects
Reg. No./Substance:
50-60-2/Phentolamine; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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