Document Detail

Pulmonary arterial thrombosis in secundum atrial septal defect.
MedLine Citation:
PMID:  3687745     Owner:  NLM     Status:  MEDLINE    
Nineteen adolescent or adult patients with secundum atrial septal defect (ASD) underwent pulmonary arteriography to evaluate the presence of proximal pulmonary arterial (PA) thrombosis. This procedure demonstrated proximal PA thrombosis in 8 patients (group 2). These patients had a distinctive hemodynamic profile, consisting primarily of significant PA hypertension. None of the 11 patients with normal angiograms (group 1) had severe PA hypertension (p less than 0.0001). Proximal PA thrombosis appears to be the major factor in the development and progression of PA hypertension in adult patients with ostium secundum ASD. Pulmonary angiography should be undertaken in all adult patients with ostium secundum ASD who have at least moderate PA hypertension. Long-term anticoagulation is advocated for patients with PA thrombosis irrespective of a decision for surgical intervention.
C L Schamroth; P Sareli; W A Pocock; R Davidoff; J King; G S Reinach; J B Barlow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  60     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-23     Completed Date:  1987-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1152-6     Citation Subset:  AIM; IM    
University of the Witwatersrand, South Africa.
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MeSH Terms
Blood Pressure
Heart Septal Defects, Atrial / complications*
Hypertension, Pulmonary / etiology,  physiopathology,  radiography
Middle Aged
Pulmonary Artery* / radiography
Thrombosis / complications*,  radiography
Vascular Resistance

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