| Pulmonary arterial responses to reactive oxygen species are altered in newborn piglets with chronic hypoxia-induced pulmonary hypertension. | |
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MedLine Citation:
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PMID: 21516056 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Reactive oxygen species (ROS) have been implicated in the pathogenesis of pulmonary hypertension. ROS might mediate vascular responses, at least in part, by stimulating prostanoid production. Our goals were to determine if the effect of ROS on vascular tone is altered in resistance pulmonary arteries (PRA) of newborn piglets with chronic hypoxia-induced pulmonary hypertension and the role, if any, of prostanoids in ROS-mediated responses. In cannulated, pressurized PRA, ROS generated by xanthine (X) plus xanthine oxidase (XO) had minimal effect on vascular tone in control piglets but caused significant vasoconstriction in hypoxic piglets. Both cyclooxygenase inhibition with indomethacin and thromboxane synthase inhibition with dazoxiben significantly blunted constriction to X+XO in hypoxic PRA. X+XO increased prostacyclin production (70±8%) by a greater degree than thromboxane production (50±6%) in control PRA; this was not the case in hypoxic PRA where the increases in prostacyclin and thromboxane production were not statistically different (78±13% versus 216±93%, respectively). Thromboxane synthase expression was increased in PRA from hypoxic piglets while prostacyclin synthase expression was similar in PRA from hypoxic and control piglets. Under conditions of chronic hypoxia, altered vascular responses to ROS may contribute to pulmonary hypertension by a mechanism that involves the prostanoid vasoconstrictor, thromboxane. ABBREVIATIONS: |
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Authors:
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Candice D Fike; Judy L Aschner; James C Slaughter; Mark R Kaplowitz; Yongmei Zhang; Sandra L Pfister |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Pediatrics [C.D.F., J.L.A., M.R.K., Y.Z.], and Biostatistics [J.C.S.)], Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN 37232; Department of Pharmacology [S.L.P.], Medical College of Wisconsin, Milwaukee, WI 53226. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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