Document Detail

Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review.
MedLine Citation:
PMID:  19324955     Owner:  NLM     Status:  MEDLINE    
According to current guidelines, pulmonary arterial hypertension (PAH) is diagnosed when mean pulmonary arterial pressure (Ppa) exceeds 25 mmHg at rest or 30 mmHg during exercise. Issues that remain unclear are the classification of Ppa values <25 mmHg and whether Ppa >30 mmHg during exercise is always pathological. We performed a comprehensive literature review and analysed all accessible data obtained by right heart catheter studies from healthy individuals to determine normal Ppa at rest and during exercise. Data on 1,187 individuals from 47 studies in 13 countries were included. Data were stratified for sex, age, geographical origin, body position and exercise level. Ppa at rest was 14.0+/-3.3 mmHg and this value was independent of sex and ethnicity. Resting Ppa was slightly influenced by posture (supine 14.0+/-3.3 mmHg, upright 13.6+/-3.1 mmHg) and age (<30 yrs: 12.8+/- 3.1 mmHg; 30-50 yrs: 12.9+/-3.0 mmHg; > or = 50 yrs: 14.7+/-4.0 mmHg). Ppa during exercise was dependent on exercise level and age. During mild exercise, Ppa was 19.4+/-4.8 mmHg in subjects aged <50 yrs compared with 29.4+/-8.4 mmHg in subjects > or = 50 yrs (p<0.001). In conclusion, while Ppa at rest is virtually independent of age and rarely exceeds 20 mmHg, exercise Ppa is age-related and frequently exceeds 30 mmHg, especially in elderly individuals, which makes it difficult to define normal Ppa values during exercise.
G Kovacs; A Berghold; S Scheidl; H Olschewski
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-03-26
Journal Detail:
Title:  The European respiratory journal     Volume:  34     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-02     Completed Date:  2009-12-30     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  888-94     Citation Subset:  IM    
Dept of Pulmonology, Medical University Graz, Graz, Austria.
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MeSH Terms
Blood Pressure*
Cardiac Catheterization / standards*
Heart Ventricles
Hypertension, Pulmonary / diagnosis*,  physiopathology*
Reference Values
Comment In:
Eur Respir J. 2009 Oct;34(4):790-1   [PMID:  19797667 ]

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