| Pulmonary arterial hypertension in patients with slow-flow vascular malformations. | |
| | |
MedLine Citation:
|
PMID: 21173318 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the prevalence of pulmonary arterial hypertension in asymptomatic patients with 2 types of extensive slow-flow vascular malformations: extensive venous malformations or Klippel-Trénaunay syndrome (KTS). DESIGN: Case-control. SETTING: Multidisciplinary center for vascular anomalies. Patients A consecutive sample of 32 patients with slow-flow vascular malformations of at least 15% of the body surface was identified retrospectively and matched by age and sex with 32 healthy controls. Interventions Standard 2-dimensional transthoracic Doppler echocardiography. Venous samples were obtained the same day that echocardiography was performed. MAIN OUTCOME MEASURES: Pulmonary artery systolic pressure (PASP) was determined. Levels of D-dimer, fibrinogen, and von Willebrand factor (vWF) in plasma were measured. RESULTS: Patients had a mean (SD) PASP that was significantly higher than that of healthy controls (42.16 [8.49] mm Hg in patients vs 27.69 [6.54] mm Hg in healthy controls; P < .001). No significant differences in PASP were found between patients with KTS and patients with venous malformations (P = .80). We observed significant differences in the mean (SD) levels of vWF between patients and healthy controls (124.41% [52.28%] in patients vs 92.69% [28.92%] in controls; P = .01) and also in levels of D-dimer (1032.99 [1367.0] ng/mL in patients vs 102.97 [29.39] ng/mL in healthy controls; P < .001). There was a moderate positive correlation between levels of vWF and levels of PASP (r = 0.42; P = .001) and a high positive correlation between D-dimer and PASP (r = 0.52; P < .001) CONCLUSIONS: The presence of pulmonary arterial hypertension in patients with extensive slow-flow vascular malformations is not an isolated feature but is relatively frequent. Levels of D-dimer correlate with PASP in these patients. |
| | |
Authors:
|
Moisés Rodríguez-Mañero; Leyre Aguado; Pedro Redondo |
Related Documents
:
|
9058668 - Antinuclear antibody positivity in pediatric patients with autoimmune thyroid disease. 17590608 - Chronic lymphocytic (hashimoto's) thyroiditis in kuwait diagnosed by fine needle aspira... 17451498 - Salivary gland parameters and clinical data related to the underlying disorder in patie... 9580758 - Bioassay of thyrotropin receptor antibodies with chinese hamster ovary cells transfecte... 22827468 - Aspirin and recurrent venous thromboembolism in patients with symptomatic atheroscleros... 9491298 - Rotatory seizures in juvenile myoclonic epilepsy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of dermatology Volume: 146 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 1347-52 Citation Subset: AIM; IM |
Affiliation:
|
Department of Dermatology, University Clinic of Navarra, 31008 Pamplona, Spain. predondo@unav.es. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8...
Next Document: Prevalence and characteristics of indoor tanning use among men and women in the United States.