Document Detail


Pulmonary arterial hypertension in patients with prior atrial switch procedure for d-transposition of great arteries (dTGA).
MedLine Citation:
PMID:  19356811     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: Our echocardiography database was reviewed for patients with a diagnosis of dTGA status post-atrial switch operation treated with pulmonary vasodilator therapy (monotherapy or combination).
RESULTS: Six patients (2 male, 4 female) were identified from 104 patients (67% male). Mean age at atrial switch was 22.1 months; mean age of PAH diagnosis was 29.3 years. Functional class improved from a baseline mean of 3.3 to 1.8 on treatment (p=0.001). No adverse events were associated with treatment. 3 of 4 patients initially referred for heart-lung transplant no longer require transplantation.
CONCLUSIONS: PAH is a late complication of the atrial switch procedure for dTGA, affecting 5.7% of our dTGA atrial switch population, with a higher incidence in female patients. In this cohort, pulmonary arterial vasodilator therapy was well tolerated and improved functional status.
Authors:
Amin Yehya; Teresa Lyle; Maria A Pernetz; M E McConnell; B Kogon; Wendy M Book
Publication Detail:
Type:  Journal Article     Date:  2009-04-07
Journal Detail:
Title:  International journal of cardiology     Volume:  143     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  271-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Emory University School of Medicine, Division of Cardiology, and the Sibley Heart Center, 1365 Clifton Rd NE Ste A2447, Atlanta, GA 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiac Surgical Procedures / adverse effects*,  methods*
Child, Preschool
Databases, Factual
Female
Heart-Lung Transplantation
Humans
Hypertension, Pulmonary / drug therapy,  etiology*,  surgery
Infant
Male
Postoperative Complications / diagnosis*,  drug therapy,  surgery
Transposition of Great Vessels / surgery*
Vasodilator Agents / therapeutic use
Young Adult
Chemical
Reg. No./Substance:
0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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