| Pulmonary arterial hypertension in patients with prior atrial switch procedure for d-transposition of great arteries (dTGA). | |
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MedLine Citation:
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PMID: 19356811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Our echocardiography database was reviewed for patients with a diagnosis of dTGA status post-atrial switch operation treated with pulmonary vasodilator therapy (monotherapy or combination). RESULTS: Six patients (2 male, 4 female) were identified from 104 patients (67% male). Mean age at atrial switch was 22.1 months; mean age of PAH diagnosis was 29.3 years. Functional class improved from a baseline mean of 3.3 to 1.8 on treatment (p=0.001). No adverse events were associated with treatment. 3 of 4 patients initially referred for heart-lung transplant no longer require transplantation. CONCLUSIONS: PAH is a late complication of the atrial switch procedure for dTGA, affecting 5.7% of our dTGA atrial switch population, with a higher incidence in female patients. In this cohort, pulmonary arterial vasodilator therapy was well tolerated and improved functional status. |
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Authors:
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Amin Yehya; Teresa Lyle; Maria A Pernetz; M E McConnell; B Kogon; Wendy M Book |
Publication Detail:
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Type: Journal Article Date: 2009-04-07 |
Journal Detail:
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Title: International journal of cardiology Volume: 143 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 271-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Emory University School of Medicine, Division of Cardiology, and the Sibley Heart Center, 1365 Clifton Rd NE Ste A2447, Atlanta, GA 30322, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiac Surgical Procedures / adverse effects*, methods* Child, Preschool Databases, Factual Female Heart-Lung Transplantation Humans Hypertension, Pulmonary / drug therapy, etiology*, surgery Infant Male Postoperative Complications / diagnosis*, drug therapy, surgery Transposition of Great Vessels / surgery* Vasodilator Agents / therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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