| Pulmonary arterial hypertension in a patient with cowden syndrome and anorexigen exposure. | |
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MedLine Citation:
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PMID: 21972386 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report a case of pulmonary arterial hypertension (PAH) occurring in a patient with Cowden syndrome with a mutation in the phosphatase and tensin (PTEN) tumor suppressor gene, in the context of exposure to the appetite suppressant dexfenfluramine. Anorexigen exposure is known to be a risk factor for PAH. However, the role of PTEN in cell function and the development of pulmonary vascular remodeling and histopathologic signs of PAH in mice with a Pten depletion in smooth muscle cells suggest that the association of PAH and Cowden syndrome may be relevant. In this case report, we hypothesize that PTEN mutations may be a predisposing factor for the development of PAH, with anorexigen exposure as a potential trigger. |
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Authors:
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Delphine Natali; Barbara Girerd; David Montani; Florent Soubrier; Gérald Simonneau; Marc Humbert; Olivier Sitbon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 140 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1066-8 Citation Subset: AIM; IM |
Affiliation:
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Service de Pneumologie et Réanimation, Hôpital Antoine Béclère, 157 rue de la Porte de Trivaux, 92140 Clamart, France. olivier.sitbon@abc.aphp.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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