Document Detail


Pulmonary argyrophil cells at high altitude.
MedLine Citation:
PMID:  886399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The numbers of individual argyrophil cells and groups of argyrophil cells were compared in rabbits which had been born and had spent their entire lives at a height of 4300 m above sea level and in sea-level controls. In the bronchi and bronchioles there were more groups of argyrophil cells in the high-altitude rabbits (mean 10-23/cm2) than in the sea-level controls (mean 5-22/cm2). In the alveolar walls there were more individual cells in the high-altitude rabbits (mean 2-65/cm2) than in the sea-level controls (mean 0-72/cm2). These differences may be either inherited or acquired and in either case, it is suggested that the likely explanation for the differences is hypoxia. If acquired, the differences may be due to differentiation of argyrophil cells from a stem cell. The results provide evidence that individual argyrophil cells exist in the alveolar walls. They suggest that individual argyrophil cells and groups of argyrophil cells may have different functions according to their site.
Authors:
W Taylor
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pathology     Volume:  122     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-29     Completed Date:  1977-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Altitude*
Animals
Bronchi / cytology
Female
Humans
Lung / cytology*
Male
Rabbits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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