| Pulmonary alveolar proteinosis: successful treatment with aerosolized trypsin. | |
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MedLine Citation:
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PMID: 425974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 37 year old man with pulmonary alveolar proteinosis and severe pulmonary physiologic impairment was treated empirically for 12 months with continuous oxygen, intermittent positive pressure breathing and aerosolized saline solution, heparin and acetylcysteine. Because of progression of disease, he was treated with aerosolized trypsin in a dose of 100,000 U twice daily for six months. This treatment was associated with dramatic symptomatic, chest roentgenographic and pulmonary physiologic improvement that has lasted for two and a half years without remission. The absence of adverse effects of trypsin aerosol allowed its administration in the patient's home. It is suggested that the preferred initial therapy for symptomatic alveolar proteinosis is aerosolized trypsin. |
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Authors:
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S J Jay |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 66 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-05-26 Completed Date: 1979-05-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 348-54 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerosols Biopsy Humans Lung / pathology Male Pulmonary Alveolar Proteinosis / drug therapy*, pathology Respiratory Function Tests Trypsin / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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