Document Detail


Pulmonary alveolar proteinosis: step-by-step perioperative care of whole lung lavage procedure.
MedLine Citation:
PMID:  11805749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pulmonary alveolar proteinosis is a rare disease characterized by the accumulation of surfactant-like material within the alveolar spaces that causes progressive respiratory failure. Improvement can be achieved with whole lung lavage. OBJECTIVE: Our objective was to conduct a study of the feasibility of treating pulmonary alveolar proteinosis in a community hospital. METHODS: Five patients were treated. We assessed procedure pulmonary functions. RESULTS: No major sequelae occurred. Each lung was lavaged with 12 to 20 L of normal saline in cycles of 970 +/- 150 mL each (mean +/- standard deviation), over 106 +/- 49 minutes. Extubation was performed when compliance of the lavaged lung was restored. All patients showed subjective improvement. Resting and exercise oxygen saturation improved within 1 week after the lavage. A significant improvement was also noted in forced expiratory volume in 1 second, forced vital capacity, and maximal oxygen uptake, whereas total lung capacity and carbon monoxide single-breath diffusion capacity remained unchanged. CONCLUSION: Although retrospective and based on a small sample size, our results suggest that whole lung lavage may be performed safely even in medical centers that have limited experience, if strict adherence to a protocol is maintained.
Authors:
Ron Ben-Abraham; Adrian Greenfeld; Judith Rozenman; Issahar Ben-Dov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  31     ISSN:  0147-9563     ISO Abbreviation:  Heart Lung     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-01-23     Completed Date:  2002-03-13     Revised Date:  2006-08-28    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Critical Care, Faculty of Medicine, Tel Aviv University, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bronchoalveolar Lavage / methods*
Feasibility Studies
Female
Hospitals, Community
Humans
Israel
Male
Middle Aged
Perioperative Care / methods*
Pulmonary Alveolar Proteinosis / therapy*
Quality of Health Care
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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