Document Detail

Pulmonary alveolar proteinosis in extremis: the case for aggressive whole lung lavage with extracorporeal membrane oxygenation support.
MedLine Citation:
PMID:  17337244     Owner:  NLM     Status:  MEDLINE    
Pulmonary alveolar proteinosis (PAP) is a rare disorder in which lipoproteinaceous material is deposited in the alveoli, compromising gaseous exchange. We report the case of a 29-year-old female patient presenting with the most extreme case of PAP yet reported. She successfully managed by aggressive bilateral whole lung lavage (WLL) in a single sitting using extracorporeal membrane oxygenation (ECMO) support. Despite critical hypercarbia and ventilator-dependence for 12 days before lavage, the patient experienced rapid recovery of pulmonary function after WLL and ECMO could be discontinued on-table. Aggressive WLL with ECMO support can be safe and effective even in the most severe cases of PAP.
Alan D L Sihoe; Vivian M W Ng; Raymond W T Liu; Lik-Cheung Cheng
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-06
Journal Detail:
Title:  Heart, lung & circulation     Volume:  17     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-03-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Division of Cardiothoracic Surgery, The University of Hong Kong, Grantham Hospital, Hong Kong SAR, China.
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MeSH Terms
Bronchoalveolar Lavage / methods
Disease Progression
Extracorporeal Membrane Oxygenation / methods*
Fiber Optic Technology
Follow-Up Studies
Pulmonary Alveolar Proteinosis / diagnosis*,  therapy*
Pulmonary Gas Exchange
Radiography, Thoracic
Respiration, Artificial / methods
Risk Assessment
Severity of Illness Index
Tomography, X-Ray Computed
Treatment Outcome

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