| Pulmonary alveolar epithelial permeability in surgically induced hemorrhagic pancreatitis in dogs. | |
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MedLine Citation:
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PMID: 6164083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adult respiratory distress syndrome has been associated with acute pancreatitis in 5-8% of patients. to determine, in a quantitative manner, the effects of acute, hemorrhagic pancreatitis on alveolar epithelial permeability, we studied two groups of dogs (group 1 - sham-operated, 7 dogs; group 2 - surgically induced pancreatitis, 7 dogs) and measured the flux of 10,000-20,000 molecular weight dextran and albumin (69,000 molecular weight), from the blood to the saline-filled lung. Following the surgical procedure (day 1), serum amylase levels increased significantly (397 +/- 70-1,268 +/- 95 dye units) in group 2 but not in group 1. Alveolar epithelial permeability (expressed as T1/2 time in minutes to 50% equilibration between blood and lung liquid) did not increase in either group for dextrans or albumin. We conclude that experimental acute pancreatitis does not cause an increase in alveolar epithelial permeability for molecular weight substances up to 69,000 daltons. |
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Authors:
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R Falls; J E Millen; F L Glauser; P Egan; B Roberts |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 40 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 1980 |
Date Detail:
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Created Date: 1981-06-23 Completed Date: 1981-06-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 213-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Dextrans / metabolism Dogs Hemorrhage / complications Molecular Weight Pancreatitis / etiology, metabolism* Permeability* Pulmonary Alveoli / metabolism*, physiopathology Serum Albumin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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