Document Detail

Pulmonary acid injury: effects of positive end-expiratory pressure and crystalloid vs colloid fluid resuscitation.
MedLine Citation:
PMID:  7041856     Owner:  NLM     Status:  MEDLINE    
Pulmonary acid aspiration results in hypoxemia and hypovolemia. We assessed the effects of positive end-expiratory pressure (PEEP) and fluid resuscitation on oxygenation and alveolar-capillary membrane permeability after acid aspiration. Alveolar-capillary membrane permeability was assessed by determination of extravascular lung water volume, using the thermal-green dye double-indicator technique, extravasation of iodinated 1 125 serum albumin into lung parenchyma, and albumin leak into the alveolar spaces. The data from this study demonstrated that PEEP improved oxygenation after acid aspiration, but did not alter progression of the injury; cardiac output and oxygen transport were improved by plasma volume repletion while receiving PEEP; and resuscitation with 5% albumin solution increased plasma albumin content and tracheal albumin content commensurately and did not modify progression of the injury.
A B Peitzman; G T Shires; H Illner; G T Shires
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  117     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  662-8     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiac Output
Fluid Therapy / methods*
Hydrochloric Acid
Lung Compliance
Oxygen / blood
Plasma Volume
Pneumonia, Aspiration / blood,  physiopathology,  therapy*
Positive-Pressure Respiration*
Serum Albumin / analysis
Grant Support
F326M07560//PHS HHS
Reg. No./Substance:
0/Colloids; 0/Serum Albumin; 7647-01-0/Hydrochloric Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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