Document Detail

Pulmonary Vasoconstrictive and Bronchoconstrictive Responses to Anaphylaxis Are Weakened via β2-adrenoceptor Activation by Endogenous Epinephrine in Anesthetized Rats.
MedLine Citation:
PMID:  21307766     Owner:  NLM     Status:  Publisher    
BACKGROUND: Patients treated with propranolol, a nonselective β-adrenoceptor antagonist, have increased incidence and severity of anaphylaxis. We determined whether β1- or β2-adrenoceptor antagonist modulated pulmonary vasoconstriction and bronchoconstriction in rat anaphylactic hypotension. METHODS:: Anesthetized ovalbumin-sensitized male Sprague-Dawley rats were randomly allocated to the following pretreatment groups (n = 7/group): (1) sensitized control (nonpretreatment), (2) propranolol, (3) the selective β2-adrenoceptor antagonist ICI 118,551, (4) the selective β1-adrenoceptor antagonist atenolol, and (5) adrenalectomy. Shock was induced by an intravenous injection of the antigen. Mean arterial pressure, pulmonary arterial pressure, left atrial pressure, central venous pressure, portal venous pressure, airway pressure, and aortic blood flow were continuously measured. RESULTS:: In either sensitized control or atenolol-pretreated rats, mean arterial pressure and aortic blood flow decreased substantially, whereas pulmonary arterial pressure and airway pressure did not increase soon after antigen injection. In contrast, in rats pretreated with either propranolol, ICI 118,551, or adrenalectomy, airway pressure significantly increased by 14 cm H2O, and pulmonary arterial pressure by 7.5 mmHg after antigen injection. At 2.5 min after antigen injection, the plasma concentration of epinephrine increased 14-fold in the sensitized rats except for the adrenalectomy group. Portal venous pressure after antigen injection increased by 16 mmHg similarly in all sensitized rats. All of the sensitized control group and two of the atenolol group were alive for 60 min after antigen injection, whereas all rats of the propranolol, ICI 118,551, and adrenalectomy groups died within 50 min after antigen injection. CONCLUSIONS:: The pulmonary vasoconstrictive and bronchoconstrictive responses to systemic anaphylaxis were weakened via β2-adrenoceptor activation by epinephrine endogenously released from the adrenal gland in the anesthetized Sprague-Dawley rats.
Wei Zhang; Toshishige Shibamoto; Yuhichi Kuda; Chieko Ohmukai; Yasutaka Kurata
Related Documents :
21316506 - Differential effect of elevated blood pressure on left ventricular geometry types in bl...
21271816 - Seasonal variation in home blood pressure measurements and relation to outside temperat...
21325646 - Neuronostatin acts in brain to biphasically increase mean arterial pressure through sym...
21361606 - Pressure cell for investigations of solid-liquid interfaces by neutron reflectivity.
19036656 - The paradox of negative pressure wound therapy--in vitro studies.
19653576 - Flying experience and cardiovascular response to rapid head-up tilt in fighter pilots.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  Anesthesiology     Volume:  -     ISSN:  1528-1175     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Graduate Student, Department of Physiology II, Kanazawa Medical University, Uchinada, Japan, and Associate Professor, Department of Pathophysiology, Medical College of Qinghai University, Xining, China; †Professor, ‡Research Fellow, §Associate Professor, Department of Physiology II, Kanazawa Medical University.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hypotension during Fluid-restricted Abdominal Surgery: Effects of Norepinephrine Treatment on Region...
Next Document:  Inflammation Confers Dual Effects on Nociceptive Processing in Chronic Neuropathic Pain Model.