Document Detail


Pulmonary vascular complications of liver disease.
MedLine Citation:
PMID:  23155142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatopulmonary syndrome and portopulmonary hypertension are two pulmonary vascular complications of liver disease. The pathophysiology underlying each disorder is distinct, but patients with either condition may be limited by dyspnea. A careful evaluation of concomitant symptoms, the physical examination, pulmonary function testing and arterial blood gas analysis, and echocardiographic, imaging, and hemodynamic studies is crucial to establishing (and distinguishing) these diagnoses. Our understanding of the pathobiology, natural history, and treatment of these disorders has advanced considerably over the past decade; however, the presence of either still increases the risk of morbidity and mortality in patients with underlying liver disease. There is no effective medical treatment for hepatopulmonary syndrome. Although liver transplantation can resolve hepatopulmonary syndrome, there appears to be worse survival even with transplantation. Liver transplantation poses a very high risk of death in those with significant portopulmonary hypertension, where targeted medical therapies may improve functional status and allow successful transplantation in a small number of select patients.
Authors:
Jason S Fritz; Michael B Fallon; Steven M Kawut
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-15
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  187     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-04-05     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-43     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Hepatopulmonary Syndrome / diagnosis,  etiology*,  pathology,  physiopathology,  therapy
Humans
Hypertension, Portal / complications
Hypertension, Pulmonary / diagnosis,  etiology*,  pathology,  physiopathology,  therapy
Liver Diseases / complications*
Liver Transplantation
Lung / pathology,  physiopathology
Prognosis
Grant Support
ID/Acronym/Agency:
K24 HL103844/HL/NHLBI NIH HHS; R01 DK056804/DK/NIDDK NIH HHS; R01 HL113988/HL/NHLBI NIH HHS; UL1 RR024148/RR/NCRR NIH HHS
Comments/Corrections
Comment In:
Am J Respir Crit Care Med. 2013 Aug 15;188(4):514   [PMID:  23947524 ]
Am J Respir Crit Care Med. 2013 Aug 15;188(4):514   [PMID:  23947525 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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