| Pulmonary Intravascular Macrophages and Lung Health: What Are We Missing? | |
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MedLine Citation:
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PMID: 22227203 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pulmonary intravascular macrophages (PIMs) are constitutively found in species such as cattle, horse, pig, sheep, goat, cats and whales, and can be induced in species such as rats, which normally lack them. It is believed that human lung lacks PIMs but there are previous suggestions of their induction in patients suffering from liver dysfunction. Recent data show induction of PIMs in bile-duct ligated rats, and humans suffering from hepato-pulmonary syndrome. Because constitutive and induced PIMs are pro-inflammatory in response to endotoxins and bacteria, there is a need to study their biology in inflammatory lung diseases such as sepsis, asthma, chronic obstructive pulmonary diseases or hepato-pulmonary syndrome. We provide a focused review of the knowledge of PIM biology to make an argument for increased emphasis and better focus on the study of human PIMs in order to better understand their potential role in the pathophysiology and mechanisms of pulmonary diseases. |
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Authors:
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David Schneberger; Karin Aharonson-Raz; Baljit Singh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-6 |
Journal Detail:
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Title: American journal of physiology. Lung cellular and molecular physiology Volume: - ISSN: 1522-1504 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Saskatchewan. |
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