| Pulmonary hypertension in heart failure. | |
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MedLine Citation:
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PMID: 20610227 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Pulmonary hypertension occurs in 60% to 80% of patients with heart failure and is associated with high morbidity and mortality. METHODS AND RESULTS: Pulmonary artery pressure correlates with increased left ventricular end-diastolic pressure. Therefore, pulmonary hypertension is a common feature of heart failure with preserved as well as reduced systolic function. Pulmonary hypertension is partially reversible with normalization of cardiac filling pressures. Pulmonary vasculature remodeling and vasoconstriction create a second component, which does not reverse immediately, but has been shown to improve with vasoactive drugs and especially with left ventricular assist devices. CONCLUSION: Many drugs used for idiopathic pulmonary arterial hypertension are being considered as treatment options for heart failure-related pulmonary hypertension. This is of particular significance in the heart transplant population. Randomized clinical trials with interventions targeting heart failure patients with elevated pulmonary artery pressure would be justified. |
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Authors:
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Maya Guglin; Hammad Khan |
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Publication Detail:
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Type: Journal Article Date: 2010-04-03 |
Journal Detail:
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Title: Journal of cardiac failure Volume: 16 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 461-74 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiology, University of South Florida, Tampa, Florida 33618, USA. mguglin@health.usf.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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