Document Detail


Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors.
MedLine Citation:
PMID:  21057104     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Idiopathic pulmonary fibrosis (IPF) is a disabling disease of the lung parenchyma, characterized by progressive accumulation of scar tissue and myofibroblast activation after repetitive epithelial microinjury. The therapeutic options are limited, and patients usually die within a few years after diagnosis. Pulmonary hypertension (PH) in IPF has been increasingly recognized as a condition with relevance for the overall prognosis. Treatment trials are being designed, but to be effective, it is crucial to better understand the pathobiology of PH in IPF: the traditional concept, that hypoxic vasoconstriction and accumulation of scar tissue are mainly responsible for the development of PH in IPF, has been challenged. Recent studies, including our own in vivo research, suggest that the underlying pathobiology is much more complex, and includes a complicated interaction of epithelial cells, fibroblasts, and vascular cells. This interaction seems to be regulated by a large variety of angiogenesis promoters and inhibitors, as well as growth factors. Central components seem to be endothelial apoptosis and growth factor-induced remodeling of the pulmonary artery wall. The present review gives a conceptual overview about known and putative mechanisms that are involved in the development of PH in IPF. This report summarizes currently available therapeutic options, and also translates experimental research to discuss potential novel biomarkers and therapeutic strategies derived from new concepts in pathogenesis.
Authors:
Laszlo Farkas; Jack Gauldie; Norbert F Voelkel; Martin Kolb
Related Documents :
15994464 - Pulmonary hypertension.
14524574 - Reversibility of medically unresponsive pulmonary hypertension with nesiritide in a car...
1790644 - Primary pulmonary hypertension associated with systemic lupus erythematosus.
9354554 - Unusual cause of pulmonary hypertension and congestive heart failure in a newborn.
10894104 - Pulmonary tissue volume measured by acetylene rebreathing under artificial ventilation.
18644114 - Emergency endovascular management of peripheral artery aneurysms and pseudoaneurysms - ...
Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  American journal of respiratory cell and molecular biology     Volume:  45     ISSN:  1535-4989     ISO Abbreviation:  Am. J. Respir. Cell Mol. Biol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917225     Medline TA:  Am J Respir Cell Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-15     Citation Subset:  IM    
Affiliation:
Departments of Medicine, Pathology and Molecular Medicine, McMaster University, Firestone Institute for Respiratory Health, 50 Charlton Avenue East, Room T2121, Hamilton, ON L8N 4A6, Canada. kolbm@mcmaster.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The logic of policy change: structure and agency in political life.
Next Document:  Functional expression of ?-amino butyric acid transporter 2 in human and guinea pig airway epitheliu...