Document Detail


[Pulmonary hypertension - historical development, current therapy and perspectives].
MedLine Citation:
PMID:  20827642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article provides a brief overview on the history of pulmonary hypertension, starting with the first descriptions of the accompanying pulmonary vascular lesions by Ernst von Romberg and Victor Eisenmenger at the end of the 19th century. Many of the histopathological changes in the pulmonary vasculature found in the various forms of pulmonary hypertension had already been described in the first half of the 20th century. However, only through the pioneering work by Forssmann and Cournand during the middle of the 20th century was it finally possible to catheterise the right ventricle and the pulmonary arteries. After this it became feasible to study the clinical spectrum of the various forms of pulmonary hypertension as well as the effects of therapeutic interventions. Early treatment attempts with vasodilators, however, were not successful. Intravenous prostacyclin, used to treat some forms of pulmonary hypertension since 1980, became the first effective treatment. Since that time, our understanding of the pathogenesis of pulmonary hypertension has increased substantially, as has the number of effective therapies, at least for some forms of pulmonary hypertension. Many aspects of the disease, however, remain poorly understood and a cure is still not achievable for the majority of the affected patients.
Authors:
M M Hoeper
Publication Detail:
Type:  English Abstract; Historical Article; Journal Article; Review     Date:  2010-09-08
Journal Detail:
Title:  Pneumologie (Stuttgart, Germany)     Volume:  64     ISSN:  1438-8790     ISO Abbreviation:  Pneumologie     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906641     Medline TA:  Pneumologie     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  577-82     Citation Subset:  IM    
Copyright Information:
Copyright Georg Thieme Verlag KG Stuttgart . New York.
Affiliation:
Klinik für Pneumologie, Medizinische Hochschule Hannover, Hannover. hoeper.marius@mh-hannover.de
Vernacular Title:
Die pulmonale Hypertonie - historische Entwicklung, derzeitiger Stand der Therapie und Ausblick.
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MeSH Terms
Descriptor/Qualifier:
History, 19th Century
History, 20th Century
Humans
Hypertension, Pulmonary / classification,  history*,  pathology,  therapy*
Pulmonary Artery / pathology,  physiopathology
Vasodilator Agents / therapeutic use
Chemical
Reg. No./Substance:
0/Vasodilator Agents

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