| Pulmonary emphysema: effect of lung volume on objective quantification at thin-section CT. | |
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MedLine Citation:
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PMID: 20663967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively investigate the effect of submaximal inspiration on computed tomographic (CT) indexes used to quantify emphysema and to discriminate between effects of lung tissue loss and increase in total lung capacity (TLC) on these indexes. MATERIALS AND METHODS: In this ethical committee-approved study, 20 control subjects and 16 patients with chronic obstructive pulmonary disease (COPD) who provided written informed consent were included. Three 1-mm-thick sections were obtained from each participant at 100%, 90%, 80%, 70%, and 50% of vital capacity (VC). At each volume, eight percentiles of attenuation distribution, as well as relative area (RA) of lung occupied by attenuation coefficients lower than nine thresholds, were calculated. A linear regression line between TLC and each CT index was plotted for control subjects. Mean distance from data points measured in patients with COPD to the normal regression line was used to reflect the effect of lung tissue loss, regardless of TLC. RESULTS: The RA of lung occupied by attenuation coefficients lower than -950 HU (RA(950)) at any percentage of VC lower than 100% decreased significantly from that at 100% VC (P ≤ .002) in control subjects and patients with COPD; however, between 100% VC and 90% VC, the average difference in RA(950) was only 3% and 2% in control subjects and patients with COPD, respectively. The 1st percentile at any percentage of VC lower than 100% increased from that at 100% VC (P < .001) in control subjects. This percentile did not significantly differ from 100% VC at 90% VC or 80% VC (P = .176 and P = 0.077, respectively), but it did significantly differ from 100% VC at 70% VC and 50% VC (P ≤ .002 for both) in patients with COPD. Slope and mean distance were different from zero for all RAs and percentiles except for mean distance for RAs between RA(900) and RA(920). CONCLUSION: Submaximal inspiration induces underestimation of pulmonary emphysema. Both lung tissue loss and TLC influence CT indexes, suggesting the need to establish normal CT values. |
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Authors:
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Afarine Madani; Alain Van Muylem; Pierre Alain Gevenois |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-27 |
Journal Detail:
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Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-29 Revised Date: 2011-06-03 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 260-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. afarine@ladner-madani.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Diving Female Humans Linear Models Lung Volume Measurements Male Middle Aged Prospective Studies Pulmonary Emphysema / pathology, radiography* Respiratory Function Tests Statistics, Nonparametric Tomography, X-Ray Computed / methods* Vital Capacity |
| Comments/Corrections | |
Comment In:
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Radiology. 2011 May;259(2):610-1; author reply 611-2
[PMID:
21502395
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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