| Pulmonary embolism after snake bite in a child with Diamond-Blackfan anemia. | |
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MedLine Citation:
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PMID: 20881870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diamond-Blackfan anemia (DBA) is a rare, congenital, pure red blood cell aplasia owing to gene defects affecting the function of ribosomal proteins, essential for erythroid maturation. Iron overload is a serious complication of chronic transfusions, which may lead to cardiac toxicity and endothelial damage. We report a case of pulmonary embolism, observed after viper bite in a transfusion-dependent child with DBA without known inherited thrombophilic factors. Embolic events are uncommon after viper bites, which they usually cause consumption coagulopathy, resulting in hypocoagulable state. DBA has not been earlier correlated with thrombotic episodes. In our patient, we suggest an iron overload-induced hypercoagulability state, which in the presence of a procoagulant substance lead to the development of a thromboembolic event. |
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Authors:
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Alexandros Makis; Antonis Kattamis; Vassilios Grammeniatis; Polyxeni Sihlimiri; Haralambos Kotsonis; Andreas Iliadis; Antigone Siamopoulou; Nikolaos Chaliasos |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 33 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-23 Completed Date: 2011-02-18 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 68-70 Citation Subset: IM |
Affiliation:
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Child Health Department, University of Ioannina Medical School, Ioannina, Greece. amakis@cc.uoi.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Anemia, Diamond-Blackfan / complications*, genetics, therapy Blood Transfusion, Autologous Child Erythrocyte Transfusion Hematopoietic Stem Cell Transplantation Humans Iron Overload / complications, genetics, therapy Male Mutation Pulmonary Embolism / complications*, genetics, therapy Ribosomal Proteins / genetics, metabolism Snake Bites / complications*, genetics, therapy Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Ribosomal Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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