| Pulmonary complications after elective liver transplantation-incidence, risk factors, and outcome. | |
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MedLine Citation:
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PMID: 22885879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: The postoperative clinical course of 212 liver transplant recipients between January 2008 and April 2010 was analyzed. These patients were treated in a single intensive care unit and received standardized postoperative care. RESULTS: During the postoperative period, 47 (22%) patients developed pneumonia, of whom 20 (43%) developed respiratory failure requiring mechanical ventilation. Univariate analysis showed that several preoperative factors (age of recipient, model for end-stage liver disease score, indication for LT, platelet count, and restrictive lung pattern revealed by preoperative pulmonary function tests) and the transfusion (blood units and fresh frozen plasma units) during the operative period were associated with pneumonia. Using multivariate analysis by logistic regression, only a restrictive lung pattern (odds ratio=3.14; 95% confidence interval, 1.51-6.51; P=0.002) and the international normalized ratio measured prior LT (OR=4.95; 95% confidence interval, 1.86-8.59; P=0.0004) were independent predictors of pneumonia after LT. CONCLUSION: Pneumonia is common among patients undergoing LT and is a major cause of morbidity. A restrictive pattern on preoperative pulmonary testing and a higher international normalized ratio measured prior LT were associated with more risk of postoperative pneumonia. |
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Authors:
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Eric Levesque; Emir Hoti; Daniel Azoulay; Isabelle Honore; Bruno Guignard; Eric Vibert; Philippe Ichai; Fadi Antoun; Faouzi Saliba; Didier Samuel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation Volume: 94 ISSN: 1534-6080 ISO Abbreviation: Transplantation Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-07 Completed Date: 2012-11-19 Revised Date: 2013-05-10 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 532-8 Citation Subset: IM |
Affiliation:
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AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France. eric.levesque@pbr.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Female France / epidemiology Hospital Mortality Humans Incidence Length of Stay Liver Transplantation / adverse effects*, mortality Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Pneumonia, Bacterial / diagnosis, epidemiology*, microbiology, mortality, therapy Predictive Value of Tests Respiration, Artificial Respiratory Insufficiency / etiology, therapy Risk Assessment Risk Factors Spirometry Surgical Procedures, Elective Time Factors Treatment Outcome Young Adult |
| Comments/Corrections | |
Comment In:
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Transplantation. 2013 Apr 15;95(7):e43
[PMID:
23545510
]
Transplantation. 2013 Apr 15;95(7):e43-4 [PMID: 23545511 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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