Document Detail


Pulmonary capillary wedge pressure augments right ventricular pulsatile loading.
MedLine Citation:
PMID:  22131357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike the systemic circulation, pulmonary vascular resistance (R(PA)) and compliance (C(PA)) are consistently and inversely related regardless of age, pulmonary hypertension, or interstitial fibrosis and that this relation may be changed by elevated pulmonary capillary wedge pressure, augmenting right ventricular pulsatile load.
METHODS AND RESULTS: Several large clinical databases with right heart/pulmonary catheterization data were analyzed to determine the R(PA)-C(PA) relationship with pulmonary hypertension, pulmonary fibrosis, patient age, and varying pulmonary capillary wedge pressure. Patients with suspected or documented pulmonary hypertension (n=1009) and normal pulmonary capillary wedge pressure displayed a consistent R(PA)-C(PA) hyperbolic (inverse) dependence, C(PA)=0.564/(0.047+R(PA)), with a near-constant resistance-compliance product (0.48±0.17 seconds). In the same patients, the systemic resistance-compliance product was highly variable. Severe pulmonary fibrosis (n=89) did not change the R(PA)-C(PA) relation. Increasing patient age led to a very small but statistically significant change in the relation. However, elevation of the pulmonary capillary wedge pressure (n=8142) had a larger impact, significantly lowering C(PA) for any R(PA) and negatively correlating with the resistance-compliance product (P<0.0001).
CONCLUSIONS: Pulmonary hypertension and pulmonary fibrosis do not significantly change the hyperbolic dependence between R(PA) and C(PA), and patient age has only minimal effects. This fixed relationship helps explain the difficulty of reducing total right ventricular afterload by therapies that have a modest impact on mean R(PA). Higher pulmonary capillary wedge pressure appears to enhance net right ventricular afterload by elevating pulsatile, relative to resistive, load and may contribute to right ventricular dysfunction.
Authors:
Ryan J Tedford; Paul M Hassoun; Stephen C Mathai; Reda E Girgis; Stuart D Russell; David R Thiemann; Oscar H Cingolani; James O Mudd; Barry A Borlaug; Margaret M Redfield; David J Lederer; David A Kass
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-30
Journal Detail:
Title:  Circulation     Volume:  125     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-04-12     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-97     Citation Subset:  AIM; IM    
Copyright Information:
© 2011 American Heart Association, Inc.
Affiliation:
Division of Cardiology, Johns Hopkins Medical Institutions, Ross 858, 720 Rutland Ave, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Databases, Factual
Heart Ventricles / physiopathology
Humans
Hypertension, Pulmonary
Lung Compliance
Pulmonary Fibrosis
Pulmonary Wedge Pressure / physiology*
Retrospective Studies
Vascular Resistance / physiology*
Ventricular Dysfunction, Right / physiopathology*
Grant Support
ID/Acronym/Agency:
5P50HL084946/HL/NHLBI NIH HHS; K23 HL086714/HL/NHLBI NIH HHS; KL2-RR024156/RR/NCRR NIH HHS; P50 HL084946-04/HL/NHLBI NIH HHS; P50 HL084946-05/HL/NHLBI NIH HHS; T32 HL007227-36/HL/NHLBI NIH HHS; T32-HL-07227/HL/NHLBI NIH HHS
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