Document Detail

Pulmonary arterial hypertension in the setting of pregnancy: a case series and standard treatment approach.
MedLine Citation:
PMID:  22139549     Owner:  NLM     Status:  MEDLINE    
Pregnancy in patients with pulmonary arterial hypertension (PAH) is associated with a maternal mortality of 30-50% despite modern treatment modalities. The majority of maternal deaths in PAH patients occur either during labor and delivery or within 1 month postpartum. Cardiovascular collapse is attributed to a mismatch between the physiologic limitations of PAH and the changes that occur with pregnancy and delivery. In the Unites States, there is no consensus on the management of PAH in pregnancy. Several case reports have been published describing improved maternal-fetal outcomes, likely due to new advanced PH therapies, earlier diagnosis of PAH, and an adoption of a multidisciplinary treatment approach. We present five cases of gravid PAH patients successfully managed at our institution with a description of our standardized multidisciplinary treatment approach.
J Shaun Smith; Julianne Mueller; Curt J Daniels
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-12-03
Journal Detail:
Title:  Lung     Volume:  190     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-08-07     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Louisville Medical Center, Louisville, KY, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Antihypertensive Agents / therapeutic use*
Enoxaparin / therapeutic use
Epoprostenol / analogs & derivatives,  therapeutic use
Hypertension, Pulmonary / drug therapy*
Postnatal Care
Pregnancy Complications, Cardiovascular / drug therapy*
Prenatal Care
Sulfonamides / therapeutic use
Young Adult
Reg. No./Substance:
0/Anticoagulants; 0/Antihypertensive Agents; 0/Enoxaparin; 0/Sulfonamides; 0/treprostinil; 35121-78-9/Epoprostenol; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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